Publications by authors named "Shu-Qi Xiao"
[Effects of glutamine on exercise-induced fatigue, skeletal muscle oxidation and liver cell apoptosis in rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
May 2021
To investigate the effects of glutamine on exercise-induced fatigue, skeletal muscle oxidation and liver cell apoptosis in rats. Twenty SPF grade SD rats aged at 8 week and weight from 180 to 220 g, were divided into control group and glutamine-treated group after one week of feeding, 10 rats in each group. The rats in the glutamine group were treated with glutamine at the dose of 1.
View Article and Find Full Text PDFIdentification of SARS-CoV-2 entry inhibitors among already approved drugs.
Acta Pharmacol Sin
August 2021
To discover effective drugs for COVID-19 treatment amongst already clinically approved drugs, we developed a high throughput screening assay for SARS-CoV-2 virus entry inhibitors using SARS2-S pseudotyped virus. An approved drug library of 1800 small molecular drugs was screened for SARS2 entry inhibitors and 15 active drugs were identified as specific SARS2-S pseudovirus entry inhibitors. Antiviral tests using native SARS-CoV-2 virus in Vero E6 cells confirmed that 7 of these drugs (clemastine, amiodarone, trimeprazine, bosutinib, toremifene, flupenthixol, and azelastine) significantly inhibited SARS2 replication, reducing supernatant viral RNA load with a promising level of activity.
View Article and Find Full Text PDFA cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2.
Signal Transduct Target Ther
October 2020
Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture.
Emerg Microbes Infect
December 2020
The emerging SARS-CoV-2 infection associated with the outbreak of viral pneumonia in China is ongoing worldwide. There are no approved antiviral therapies to treat this viral disease. Here we examined the antiviral abilities of three broad-spectrum antiviral compounds gemcitabine, lycorine and oxysophoridine against SARS-CoV-2 in cell culture.
View Article and Find Full Text PDFArticle Synopsis
- - The study focused on Hepatitis E virus (HEV) in swine, specifically examining bile and serum samples from a slaughterhouse and farms in Shandong province, China, to identify the virus’s genotypes and assess antibody prevalence.
- - Out of 106 bile samples tested, 30.2% were positive for HEV, with the majority belonging to genotype 4, and a complete genome sequence of subtype 4d was identified.
- - The results showed a 100% seroprevalence of HEV IgG antibodies among the herds and a significant presence of IgG (66.4%) in individual pigs, raising concerns about the risks of zoonosis and food safety regarding pork products.
Article Synopsis
- * The study aimed to investigate the antigenic domains in ORF3 of a specific avian HEV isolate by creating various antigens and using different antibodies from infected mice and chickens.
- * Researchers identified three key antigenic domains in ORF3, with one being particularly dominant, which is significant for developing diagnostic immunoassays for avian HEV infection.
The purpose of this study was to determine the proper concentration of wortmannin that effectively inhibits PI3K/AKT but does not affect the proliferation and apoptosis of primary porcine preadipocytes. Firstly, primary porcine preadipocytes were isolated and their abilities to be induced to differentiation into mature adipocytes were evaluated. The preadipocytes were then treated with different concentrations of wortmannin, and the proliferation of the cells was detected with methanethiosulfonate (MTS).
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