The crystal structure of red fluorescent protein TagRFP-T reveals the mechanism of its superior photostability.

The red fluorescent protein variant TagRFP-T has greatly improved photostability over its parent molecule, TagRFP, but the underlying mechanism leading to this improvement is to date unknown. The 1.95 Å resolution crystallographic structure of TagRFP-T showed that its chromophore exists as a mixture of cis and trans coplanar isomers in roughly equal proportions.

MiR-378 suppresses prostate cancer cell growth through downregulation of MAPK1 in vitro and in vivo.

Prostate cancer is one of the biggest health problems for the aging male. To the present, the roles of dysregulated microRNAs in prostate cancer are still unclear. Here, we evaluated the anti-proliferative role of miR-378 in prostate cancer.

MiR-345 suppresses proliferation, migration and invasion by targeting Smad1 in human prostate cancer.

Introduction: The roles of dysregulated microRNAs in prostate cancer metastasis are still unknown. In this study, we found that the expression of miR-345 was significantly downregulated in prostate cancer and clinical prostate cancer tissues.

Materials, Methods And Results: Overexpression of miR-345 in prostate cancer cells suppressed proliferation, migration and invasion.

[The clinical analysis of 62 cases of the urothelial inverted papilloma].

Objective: To investigate the clinical manifestation, biological behavior, diagnosis and treatment of the urothelial inverted papilloma.

Methods: Sixty-two cases of urothelial inverted papilloma were analyzed retrospectively from January 1990 to August 2008. Of the 62 patients, 51 were men and 11 were women.