Publications by authors named "Shu-Ping Wong"
Article Synopsis
- - The study investigated the rates and predictors of oral and gastrointestinal mucositis in patients undergoing hematopoietic stem cell transplant (HSCT), emphasizing the relationship between inflammation markers and mucositis severity.
- - Over 142 patients were monitored, revealing high prevalence rates of oral (68.3%) and gastrointestinal mucositis (95.8%), with factors like specific treatment regimens and patient characteristics significantly affecting mucositis severity.
- - Cytokine levels in saliva and plasma were linked to the severity of oral mucositis, providing valuable real-world insights for managing and predicting mucositis in HSCT patients.
Mucositis is a debilitating complication of hematopoietic stem cell transplantation (HSCT). It is unclear how changes in the composition of microbiota, which are modulated by geographical location and ethnicity, may influence immune regulation leading to the development of mucositis, and the study of both oral and gut microbiota in a single population of autologous HSCT in the Asian region is lacking. The present study aimed to characterize the oral and gut microbiota changes, and the impact on both oral and lower gastrointestinal (GI) mucositis, with associated temporal changes in a population of adult recipients of autologous HSCT.
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- A randomized trial compared filgrastim and pegfilgrastim for peripheral blood stem cell mobilization (PBSCM) in patients receiving cyclophosphamide, analyzing various timing for pegfilgrastim administration.
- Pegfilgrastim given on day 7 resulted in the highest mobilization success rate (70.8%), compared to daily filgrastim (63.6%) and pegfilgrastim on day 3 (47.6%).
- The study found multiple myeloma patients were more successful in mobilization than those with acute leukemia or lymphoma, while pegfilgrastim helped avoid excessive white blood cell increases compared to filgrastim, with no significant difference in recovery times for white blood