[Expression of mesothelin mRNA and protein in ovarian carcinomas].

Objective: To investigate the expression of mesothelin (MESO) mRNA and protein and its significance in ovarian carcinomas.

Methods: Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry were used to detect the expression level of MESO mRNA and protein, respectively, in 124 samples of ovarian tumor and normal tissues, including 84 epithelial ovarian carcinomas, 12 borderline ovarian tumors, 16 benign ovarian tumors and 12 normal ovarian tissues.

Results: The expression of MESO mRNA and protein in epithelial ovarian carcinomas (1.