Hemoglobin Improves Sophorolipid Production in O-13-1 Under Oxygen Limited Conditions.

Sophorolipids (SLs) are homologous microbial secondary metabolites produced by and have been widely applied in many industrial fields. The biosynthesis of SLs is a highly aerobic process and is often limited by low dissolved oxygen (DO) levels. In this study, the hemoglobin (VHb) gene was transformed into O-13-1 by homologous recombination to alleviate oxygen limitation.

Regional homogeneity of spontaneous brain activity in adult patients with obsessive-compulsive disorder before and after cognitive behavioural therapy.

Background: Cognitive behavioural therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD). Several neuroimaging studies have explored alterations of brain function in OCD patients as they performed tasks after CBT. However, the effects of CBT on the neural activityin OCD during rest remain unknown.

Inositol and phosphatidylinositol mediated mediated glucose derepression, gene expression and invertase secretion in yeasts.

Glucose repression occurs in many yeast species and some filamentous fungi, and it represses the expression and secretion of many intracellular and extracellular proteins. In recent years, it has been found that many biochemical reactions in yeast cells are mediated by phosphatidylinositol (PI)-type signaling pathway. However, little is known about the relationships between PI-type signaling and glucose repression, gene expression and invertase secretion in yeasts.