Publications by authors named "Shu-Li Xu"

There is a lack of evidence regarding associations of eye-level greenness exposure with blood pressure among children. We aimed to investigate the associations between different types of eye-level greenness and pediatric blood pressure in China. From 2012 to 2013, we recruited 9354 children aged between 5 and 17 years in northeast China.

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Anthropogenic climate change will have a negative impact on worldwide well-being over and above the direct consequences of rising average temperatures. But anthropogenic heat (AH) relationship with childhood attention deficit hyperactivity disorder (ADHD) is unknown. To assess the relationship with AH exposure and childhood ADHD symptoms in the context of global climate change, this study was conducted in a cross-sectional survey from April 2012 to May 2018 in the northeastern, northwestern, and southern regions of China, with a total enrollment of 179,846 children aged 6-18 years.

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Objectives: Evidence on the link between long-term ambient particulate matter (PM) exposures and childhood sleep disorders were scarce. We examined the associations between long-term exposures to PM and PM (PM with an aerodynamic equivalent diameter <2.5 μm and <1 μm, respectively) with sleep disorders in children.

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Article Synopsis
  • The study investigates the link between exposure to chlorinated paraffins (CPs), a type of persistent organic pollutant, and the prevalence of allergic diseases in children and adolescents in the Pearl River Delta region of China.
  • A survey with 131,304 participants highlighted that increased levels of CPs in particulate matter are significantly associated with allergic rhinitis, atopic eczema, and allergic conjunctivitis, showing specific odds ratios for each condition.
  • The research suggests that overweight and obese individuals may be at an even higher risk for these allergic diseases; however, further studies are necessary to confirm these findings and explore the underlying mechanisms.
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The emissions and exposure limits for airborne PM are lacking, with limited scientific data for toxicity. Therefore, we continuously monitored and calculated the number and mass concentrations of airborne PM in December 2017, January 2018 and March 2018 during the high pollution period in Guangzhou. We collected PM from the same period and analyzed their chemical components.

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Article Synopsis
  • This study investigates the sources and toxicological effects of particulate matter (PM) collected in Guangzhou during a high air pollution season, focusing on the relationships between PM size, its chemical components, and how they affect cellular health.
  • The research shows that smaller PM contains more water-soluble ions and PAHs, while larger PM includes more metallic elements, with traffic exhaust, soil dust, and biomass burning being significant sources of pollution.
  • Findings reveal exposure to PM causes cell damage, including reduced mitochondrial activity and increased oxidative stress, with coarse PM also causing notable inflammatory effects, underscoring the importance of considering all PM sizes in health assessments.
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Thallium (Tl) is a cumulative high toxicant in the environment, but few studies have investigated the comprehensive health effects underlying chronic Tl exposure at trace levels. This study aims to evaluate the liver, kidney, lung and other potential health effects associated with chronic Tl exposure at trace levels in rural areas of China. Urinary Tl concentrations of 2883 adults from rural areas of 12 provinces in China were measured and 2363 participants were involved in the final analysis.

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  • The study investigates the relationship between long-term exposure to ultra-fine particles (UFPs) and obesity in children in Northeastern China, highlighting a gap in previous research on air pollution's impact on childhood obesity.
  • The researchers analyzed data from nearly 48,000 children aged 6-18 and found that higher UFP exposure correlated with increased BMI Z-scores and obesity prevalence, especially among boys and those living near busy roads.
  • The findings suggest that reducing UFP exposure could be important for addressing childhood obesity, emphasizing the need for more comprehensive air quality monitoring.
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The sources and chemical components of urban air particles exhibit seasonal variations that may affect their hazardousness to human health. Our aims were to investigate winter and spring variation in particulate matter (PM) sources, components and toxicological responses of different PM size fractions from samples collected in Guangzhou, China. Four size-segregated PM samples (PM, PM, PM, and PM) were collected separately during winter (December 2017 and January 2018) and spring (March 2018).

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Little evidence is available regarding the impact of different sizes of inhaled particulate matter (PM) on inflammatory responses in healthy young adults in connection with toxicological responses. We conducted a five-time repeated measurement panel study on 88 healthy young college students in Guangzhou, China from December 2017 to January 2018. Blood samples were collected from each participant and tested for tumor necrosis factor alpha (TNF-α) levels every week for 5 consecutive weeks.

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Previous studies have indicated that outdoor light at night (LAN) is associated with a higher prevalence of overweight or obesity in adults. However, the association of LAN levels with overweight or obesity in children is still unknown. This study utilized data from the Seven Northeastern Cities study, which included 47,990 school-aged children and adolescents (ages 6-18 years).

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Ambient particles with aerodynamic diameter <0.1 μm (PM) have been suggested to have significant health impact. However, studies on the association between long-term PM exposure and human blood lipid metabolism are still limited.

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Background: Previous studies have revealed that current secondhand smoke exposure showed highly suggestive evidence for increased risk of simultaneous sleep problems in children. Data on the associations between early-life exposure to SHS with subsequent sleep problems in children were scarce. We aimed to evaluate the associations of early-life SHS exposure with sleep problems in children.

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Background: Beneficial effects of greenness on birth outcomes have been reported, but few studies have investigated the associations in both urban and non-urban settings. We aimed to evaluate and compare linear and nonlinear associations between greenness and birth outcomes in urban and non-urban settings.

Methods: From October 2015 to December 2018, participants were recruited into the Maoming Birth Cohort Study.

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Background: Urban greenness may protect against obesity, but very few studies have assessed 'street view' (SV) greenness metrics, which may better capture people's actual exposure to greenness compared to commonly-used satellite-derived metrics. We aimed to investigate these associations further in a Chinese adult study.

Methods: Our analysis included 24,845 adults in the 33 Chinese Community Health Study in 2009.

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Article Synopsis
  • The study investigates the link between secondhand smoke (SHS) exposure and ADHD symptoms in children, assessing different exposure periods (prenatal, early postnatal, current).
  • Conducted in Liaoning province, China, the study involved over 45,000 children aged 6 to 18, collecting data from parents via questionnaires administered by teachers.
  • Results indicate that children exposed to SHS have significantly higher odds of developing ADHD symptoms, with those consistently exposed from pregnancy through childhood at the greatest risk.
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Evidence of the effects of various particle sizes and constituents on blood biomarkers is limited. We performed a panel study with five repeated measurements in 88 healthy college students in Guangzhou, China between December 2017 and January 2018. Mass concentrations of particles with aerodynamic diameters ≤ 2.

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Existing evidence is scarce concerning the various effects of different PM sizes and chemical constituents on blood lipids. A panel study that involved 88 healthy college students with five repeated measurements (440 blood samples in total) was performed. We measured mass concentrations of particulate matter with diameters ≤ 2.

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Background: Little is known about whether exposure to pets influences the association between hypertension and environmental tobacco smoke (ETS). The current study aims to examine the interaction of pet ownership on ETS exposure and the development of hypertension in children.

Methods: From 2012 to 2013, a total of 9354 children, 5 to 17 years of age, were recruited from 62 schools in seven northeastern cities.

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Evidence on the associations between airborne particulates of diameter ≤1 μm (PM) and airborne particulates of diameter ≤2.5 μm (PM) and childhood blood pressure (BP) is scarce. To help to address this literature gap, we conducted a study to explore the associations in Chinese children.

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No evidence exists concerning the association between blood pressure and ambient particles with aerodynamic diameter ≤ 1.0 µm (PM), a major component of PM (≤ 2.5 µm) particles, and potentially causing more hazardous health effects than PM.

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Article Synopsis
  • Long-term exposure to ambient air pollution was studied in relation to prehypertension, which is often overlooked compared to hypertension.
  • The research analyzed data from 24,845 adults in Northeastern China, linking higher levels of pollutants like PM, SO, NO, and O to increased cases of prehypertension and elevated blood pressure.
  • Findings indicated that the effects of air pollution on prehypertension were stronger than those on hypertension, particularly among women and older individuals, highlighting the importance of addressing air quality to prevent cardiovascular issues.
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Prior investigations on the associations of polyfluoroalkyl substances (PFASs) with fetal growth are mixed. Moreover, little research has accrued pertaining to the association between isomers of PFASs with gestational age and birth weight. To address this gap and present novel information, we conducted a study including 321 pairs of mothers and their infants recruited from Guangzhou, China.

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The impact of ambient air pollution on health causes concerns in China. However, little is known about the association of short-term air pollution exposure with blood pressure (BP) in children. The goal of present study was to assess the association between short-term air pollution and BP in children from a highly polluted area in China.

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Article Synopsis
  • Previous research has linked serum levels of perfluoroalkyl substances (PFASs) to asthma and related biomarkers, but not specifically to lung function in children.
  • This study involved 132 asthmatic children and 168 non-asthmatic controls to examine the relationship between PFAS exposure and lung function using questionnaires and spirometry.
  • Results indicated higher PFAS levels in asthmatic children compared to controls and showed a negative association between PFAS levels and lung function metrics, suggesting PFASs adversely affect lung function in asthmatic children but not in those without asthma.
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