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Publications by authors named "Shu-Jun Wan"

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Synopsis of recent research by authors named "Shu-Jun Wan"

  • - Shu-Jun Wan's recent research focuses on understanding the molecular mechanisms underlying metabolic diseases, particularly type 2 diabetes mellitus (T2DM) and related complications, through the exploration of RNA modifications like m6A methylation and the role of long non-coding RNAs (lncRNAs).
  • - Findings indicate that Metformin enhances m6A methylation to mitigate apoptosis in pancreatic β-cells, while increased serum levels of extrachromosomal circular DNA SORBS1 correlate with insulin resistance in newly diagnosed T2DM patients, suggesting the potential diagnostic significance of these biomarkers.
  • - Additional studies reveal that certain lncRNAs, such as HEM2ATM, can improve obesity-associated inflammation and insulin resistance, and decreased levels of urine m6A are linked to the presence of diabetic nephropathy, highlighting novel pathways for therapeutic intervention in diabetes-related complications.

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