Icariin induces irisin/FNDC5 expression in C2C12 cells via the AMPK pathway.

Backgroud Icariin, a major bioactive pharmaceutical component of the Chinese herbal medicine Epimedii Herba, has demonstrated lipid-lowering and anti-obesity effects. Irisin/ fibronectin type III domain-containing 5 (FNDC5) protects against obesity by inducing browning in white adipose tissue. Objectives This study investigated the effects of icariin on irisin/FNDC5 expression in C2C12 myotubes.

Browning of Abdominal Aorta Perivascular Adipose Tissue Inhibits Adipose Tissue Inflammation.

Background: Perivascular adipose tissue (PVAT) can regulate vascular homeostasis by secreting various adipokines. This study investigated the effects of PVAT browning on its endocrine function.

Methods: In the first section of our study, male Sprague-Dawley rats were randomly divided into cold exposure (8°C) and 24°C acclimation groups.

Oestrogen exerts anti-inflammation via p38 MAPK/NF-κB cascade in adipocytes.

Background: Oestrogen has anti-inflammatory property in obesity. However, the mechanism is still not defined.

Objective: To investigate the effect of oestrogen on LPS-induced monocyte chemoattractant protein-1 (MCP-1) production in adipocytes.

The role of caveolin1 and sprouty1 in genistein's regulation of vascular smooth muscle cell and endothelial cell proliferation.

Genistein prevents atherosclerosis by exerting protective effects on blood vessels. The aim of this study is to investigate the role of caveolin1 and sprouty1 in the regulation of proliferation of vascular smooth muscle cell (VSMC) and endothelial cell by genistein. Using thiazolyl blue tetrazolium bromide(MTT) and [3H]-TdR assay, we found genistein inhibited angiotensin II-induced proliferation in primary cultured VSMC while it stimulated proliferation of quiescent endothelial cells.

[Synthesis and properties of nanorod-long afterglow BaAl2O4:Eu2+, Dy3+ phosphor].

The present paper mainly reports a new method to synthesize long afterglow photoluminescent material BaAl2O4:Eu2+, Dy3+. Al(NO3)3.9H2O, Ba(NO3)2, urea, RE(NO3) 3(RE==Eu, Dy) were employed as raw materials, the admixture of H2O/n-butanol and H2O/n-butanol/SBS were used as medium, then BaAl2O4:Eu2+, Dy3+ phosphor was achieved by calcining the precursor, which was synthesized by hydrothermal method, at 130 degrees C under reduction atmosphere.

[Comparative study of antegrade and retrograde intramedullary nailing for the treatment of humeral shaft fractures].

Objective: To compare therapeutic effects between antegrade intramedullary nailing and retrograde intramedullary nailing for the treatment of humeral shaft fractures.

Methods: From March 1999 to October 2006, 105 patients with humeral shaft fractures were treated with locked intramedullary nail and were adequately followed up. There were 82 antegrade nailing and 23 retrograde nailing.

[Antibiotic-PMMA beads combined with external fixator for treating the infected fracture nonunion].

Objective: To investigate the effects of antibiotic-PMMA (polymethyl-methacrylate) beads combined with external fixator in treatment of infected fracture nonunion.

Methods: Twenty-two cases of infected fracture-nonunions were reviewed involving 20 male and 2 female with an average age of 34.68 years (ranging 21 to 74 years).