Publications by authors named "Shu-Hang Lin"
Bioinform Adv
September 2023
Article Synopsis
- Protein kinases are key signaling proteins that help maintain cell balance, but when they malfunction, they can lead to various diseases, making them prime targets for drug development.
- Kinase activity can switch between active and inactive forms, which creates unique environments for targeted drug design; understanding these conformational states is crucial for creating effective kinase inhibitors.
- The study leverages AlphaFold2's ability to predict different kinase structures, discovering that it can model various conformations while also providing insights into their flexibility and enhancing drug discovery efforts.
