Publications by authors named "Shu-Han Si"
Objectives: To observe the effect of electroacupuncture on miR-142-5p and ADAMTS1/PI3K/AKT pathway in rats with ischemic stroke, so as to explore the regulatory mechanism of electroacupuncture on angiogenesis after ischemic stroke.
Methods: This study was divided into two parts. The first part of the experiment：SD rats were randomly divided into sham operation group, model group and electroacupuncture group.
Objective: To observe the angiogenesis effect of electroacupuncture (EA) at Shuigou acupoint (GV 26) in the treatment of cerebral ischemia, and explore the value of miRNA-7 (miR-7) in it.
Methods: First, 48 mice were randomly divided into sham operation, middle cerebral artery occlusion (MCAO) model, and EA treatment groups. Then 9 mice were divided into carrier control group, miR-7 knockout group and miR-7 overexpression group (n=3 each group).
Background: Dysregulation of long noncoding RNA (lncRNA) expression is related to aging and age-associated neurodegenerative diseases, and the lncRNA expression profile in the aging hippocampus is not well characterized. In the present investigation, the changed mRNAs and lncRNAs were confirmed via deep RNA sequencing. GO and KEGG pathway analyses were conducted to investigate the principal roles of the clearly dysregulated mRNAs and lncRNAs.
View Article and Find Full Text PDFArticle Synopsis
- EMT is important for tumor metastasis and involves changes in gene expression due to epigenetic modifications, specifically the tri-methylation of histone H3 lysine 4 (H3K4me3).* -
- In prostate cancer cells, TGF-Beta1 triggers increased H3K4me3 and RbBP5 binding near the Snail gene, and knocking down RbBP5 reduces Snail expression and EMT.* -
- The study connects SMAD2/3 signaling to Snail transcription through H3K4me3 modification, suggesting that RbBP5 and WRAD could be potential targets for prostate cancer treatment.*