BRAF mutation does not predict lymph node metastases and recurrence in Chinese papillary thyroid microcarcinoma patients.

Object: Previous studies suggest BRAF mutation is a marker for poor prognosis in papillary thyroid cancer, however, its ability to further risk stratify papillary thyroid microcarcinoma (PTMC) remains controversial. We aimed to explore the association between BRAF mutation and the clinicopathological features and recurrence in Chinese PTMC patients.

Methods: We retrospectively reviewed 2094 PTMC patients who underwent surgery and had a valid BRAF mutation test result.

Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories.

Background: Detection of the pathological and disease-associated alpha-synuclein (αSyn) in the brain is required to formulate the definitive diagnosis of multiple system atrophy (MSA) and Parkinson's disease (PD). We recently showed that αSyn can be detected in the olfactory mucosa (OM) of MSA and PD patients. For this reason, we have performed the first interlaboratory study based on α-synuclein Real-Time Quaking-Induced Conversion (αSyn_RT-QuIC) analysis of OM samples collected from PD and MSA patients with the parkinsonian (MSA-P) and cerebellar (MSA-C) phenotypes.

[Evaluation of the quality of human settlement in downtown Fuzhou based on multi-source data].

The objective evaluation of human settlement in cities helps find the problems exposed in urban development and make targeted adjustments to improve urban environment. Taking the downtown of Fuzhou as the research area, the residential area as the research unit, using multi-source data such as meteorological monitoring data, remote sensing imagery, map points of interest data (POI), and land planning data, we constructed monitoring system of urban human settlement from four aspects: environmental health and comfort, traffic convenience, city safety, and life conve-nience. The TOPSIS method was used to conduct a comprehensive evaluation of human settlement.

Risk factors of recurrence and poor survival in curatively resected hepatocellular carcinoma with microvascular invasion.

Background: Microvascular invasion (MVI) is a significant sign of the invasive property and a strong predictor of poor prognosis in hepatocellular carcinoma (HCC), a life-threatening malignancy. However, recurrence-associated and post-surgical long-term prognosis-associated factors in HCC with MVI remain unknown.

Objectives: To address the abovementioned issues, based on a Chinese patient cohort with HCC after curative hepatic resection.

The prognostic value and non-invasive predictors of splenomegaly in cirrhotic patients with hepatocellular carcinoma following curative resection.

Background: The prognostic value and non-invasive predictors of splenomegaly in cirrhotic patients with hepatocellular carcinoma (HCC) after curative resection remain unknown.

Objectives: To investigate the prognostic value and non-invasive predictors of splenomegaly in cirrhotic patients with HCC after curative resection.

Material And Methods: The medical records of 78 patients with HCC and liver cirrhosis who underwent curative resection were retrospectively reviewed.

The image quality, lesion detectability, and acquisition time of F-FDG total-body PET/CT in oncological patients.

Purpose: The purpose was to investigate the effects of short acquisition time on the image quality and the lesion detectability of oncological F-FDG total-body PET/CT.

Methods: Nineteen oncological patients (6/13 women/men, age 65.6 ± 9.

Prognostic Value of ALT, AST, and AAR in Hepatocellular Carcinoma with B-Type Hepatitis-Associated Cirrhosis after Radical Hepatectomy.

Background: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and AST to ALT ratio (AAR) were shown to be associated with prognosis in some groups of hepatocellular carcinoma (HCC). However, their clinicopathologic and prognostic roles in HCC patients with B-type hepatitis-associated cirrhosis (HBAC) have not been comprehensively investigated. The present study aimed to address the issues.

Size-independent neural networks based first-principles method for accurate prediction of heat of formation of fuels.

Neural network-based first-principles method for predicting heat of formation (HOF) was previously demonstrated to be able to achieve chemical accuracy in a broad spectrum of target molecules [L. H. Hu et al.

A Highly Solvent-Stable Metal-Organic Framework Nanosheet: Morphology Control, Exfoliation, and Luminescent Property.

Compared to bulk metal-organic framework (MOF), 2D MOF nanosheets have gained intensive research attention due to their ultrathin thickness and large surface area with highly accessible active sites. However, structural deterioration and morphological damage have impeded producing high-quality MOF nanosheets during exfoliation. Here, first a new layered bulk MOF ZSB-1 is synthesized and several solvents such as isopropanol, methanol, n-hexyl alcohol, and N,N-dimethylformamide are surveyed to examine their performance for the exfoliation of layered ZSB-1.

Carbohydrate Antigen 19-9 Increases the Predictive Efficiency of α-Fetoprotein for Prognosis of Resected Hepatocellular Carcinoma.

Serum α-fetoprotein (AFP) is a classical biomarker for both diagnosis and prognosis of hepatocellular carcinoma (HCC). However, its predictive efficiency for prognosis remains unsatisfactory. This study explores whether integrating AFP and carbohydrate antigen (CA) 19-9/carcinoembryonic antigen (CEA) increase its prognostic efficiency in HCC.

Edmondson-Steiner grade: A crucial predictor of recurrence and survival in hepatocellular carcinoma without microvascular invasio.

Background: Microvascular invasion (MVI), an important pathologic parameter, has been proven to be a powerful predictor of long-term prognosis in hepatocellular carcinoma (HCC). However, prognostic factors in HCC without MVI remain unknown. The present study aimed to identify the risk factors of recurrence and poor post-resectional survival in this type of HCC.

Exploring the Detection of Metal Ions by Tailoring the Coordination Mode of V-Shaped Thienylpyridyl Ligand in Three MOFs.

By employing a rational design approach, we synthesized three luminescent metal-organic frameworks (MOFs) 1-3 affording different coordination modes of V-shaped thienylpyridyl ligand. Their application in detecting metal ions was explored, and the mechanism was inferred. And the result exhibits that MOF 3 is a dual-responsive luminescent probe for Fe and Al ions.

Cd-Based metal-organic frameworks from solvothermal reactions involving in situ aldimine condensation and the highly sensitive detection of Fe ions.

Four Cd(ii)-based compounds (1-4) were synthesized from solvothermal reactions involving the in situ aldimine condensation of an o-diamino-functionalized precursor 3,6-di(4H-imidazol-4-yl)benzene-1,2-diamine (L), Cd(NO)·4HO and aldehyde. Two modes of cycloaddition ([4 + 1] cycloaddition and [4 + 2] cycloaddition) occurred during condensation, causing the in situ generation of two benzimidazole derivative ligands (L1 and L3) and a quinoxaline derivative ligand (L2). Furthermore, the chemical selectivity of the condensation was studied, where the condensation of o-diamino and the aldehyde is more stable and easy to operate.

Research progress and prospects of markers for liver cancer stem cells.

Liver cancer is a common malignancy and surgery is the main treatment strategy. However, the prognosis is still poor because of high frequencies of postoperative recurrence and metastasis. In recent years, cancer stem cell (CSC) theory has evolved with the concept of stem cells, and has been applied to oncological research.

Interference and Molecular Transport-A Dynamical View: Time-Dependent Analysis of Disubstituted Benzenes.

The primary issue in molecular electronics is measuring and understanding how electrons travel through a single molecule strung between two electrodes. A key area involves electronic interference that occurs when electrons can follow more than one pathway through the molecular entity. When the phases developed along parallel pathways are inequivalent, interference effects can substantially reduce overall conductance.

Downregulation of KIF1B mRNA in hepatocellular carcinoma tissues correlates with poor prognosis.

Aim: To compare kinesin family member 1B (KIF1B) expression with clinicopathologic parameters and prognosis in hepatocellular carcinoma (HCC) patients.

Methods: KIF1B protein and mRNA expression was assessed in HCC and paracarcinomatous (PC) tissues from 68 patients with HCC using Western blot and quantitative real-time reverse transcription-PCR, respectively. Student's t-tests were used to analyze relationships between clinicopathologic parameters and KIF1B expression, the Kaplan-Meier method was used to analyze survival outcomes, and the log-rank test was used to compare survival differences between groups.

Early recurrence in large hepatocellular carcinoma after curative hepatic resection: prognostic significance and risk factors.

Background/aims: So far, prognostic significance and risk factors of early recurrence after curative resection in large hepatocellular carcinoma (LHCC) remain unclear. The present study aimed to answer these questions.

Methodology: Clinical, pathologic and follow-up data of consecutive 116 patients with LHCC (>5cm) after curative resection were collected and analyzed.

Risk factors of microvascular invasion, portal vein tumor thrombosis and poor post-resectional survival in HBV-related hepatocellular carcinoma.

Background/aims: Microvascular invasion (MVI) and portal vein tumor thrombosis (PVTT) associated factors in hepatocellular carcinoma (HCC) were previously shown. However, those for HBV-related HCC remain unknown. This study aimed to investigate the risk factors of MVI, PVTT and poor prognosis in this type of HCC.

Clinicopathological predictors of poor survival and recurrence after curative resection in hepatocellular carcinoma without portal vein tumor thrombosis.

Many factors associated with long-term outcome in hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) were previously identified. However, those in HCC without PVTT have not been elucidated. This study was designed to define the risk factors of poor post-surgical survival and recurrence in this subgroup of HCC.

Risk factors of poor prognosis and portal vein tumor thrombosis after curative resection of solitary hepatocellular carcinoma.

Background: Predictors of poor prognosis of solitary hepatocellular carcinoma (SHCC), a subgroup encompassing most patients with the malignancy, are still controversial. Hence, risk factors for portal vein tumor thrombosis (PVTT) in SHCC are obscure. The present study was designed to address this issue.

Collective total synthesis of englerin A and B, orientalol E and F, and oxyphyllol: application of the organocatalytic [4+3] cycloaddition reaction.

The concise collective total synthesis of englerin A and B, orientalol E and F, and oxyphyllol has been accomplished in 10-15 steps, with the total synthesis of orientalol E and oxyphyllol being achieved for the first time. The success obtained was enabled by the realization of the [4+3] cycloaddition reaction of 9 and 10. Other features of the synthesis include 1) the intramolecular Heck reaction to access the azulene core, 2) the epoxidation-S(N)2' reduction sequence to access the allylic alcohol, 3) the efficient regioselective and stereoselective formal hydration of the bridging C=C bond in the synthesis of englerins, and 4) the late-stage chemo- and stereoselective C-H oxidation in the synthesis of orientalol E.

The significance of serum AFP cut-off values, 20 and 400 ng/mL in curatively resected patients with hepatocellular carcinoma and cirrhosis might be of difference.

Background/aims: The significance of preoperative serum a-fetoprotein (AFP) level in hepatocellular carcinoma (HCC) treated with different modalities remains controversial. Besides, many cut-off values have been used. The present study aims to clarify significance of two major ones in HCC with cirrhosis.