Publications by authors named "Shu-Chih Hsieh"
A novel approach of making a biomimetic nerve conduit was established by seeding adipose-derived adult stem cells (ADSCs) on the external wall of porous poly(d,l-lactic acid) (PLA) nerve conduits. The PLA conduits were fabricated using gas foaming salt and solvent-nonsolvent phase conversion. We examined the effect of two different porous structures (GS and GL) on ADSC growth and proliferation.
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- Chitosan, combined with nerve growth factor (NGF), was immobilized on poly (lactic acid-co-glycolic) conduits to enhance surface properties for nerve regeneration, using EDC/NHS/MES and genipin as cross-linking agents.
- Four different conduit groups were created based on the order of immobilization, with the GP-cross-linked chitosan showing improved hydrophilicity and cell compatibility compared to pure PLGA.
- The GP/EDCs group displayed the most effective NGF release and showed the highest number of myelinated axons in a rat nerve defect model, demonstrating significant potential for promoting peripheral nerve regeneration.
In this study, a series of natural biodegradable materials in the form of chitosan (C)-alginate (A)-hyaluronate (H) complexes are evaluated as tissue-engineering scaffolds. The weight ratio of C/A is 1 : 1 or 1 : 2. Sodium hyaluronate is mixed in 2%.
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