Publications by authors named "Shu-Bin Lin"
Background: The effect of pain genes (NAV1, EHMT2, SP1, SLC6A4, COMT, OPRM1, OPRD1, CYP2D6, and CYP3A4) have not been reported previously in kidney renal clear cell carcinoma (KIRC) patients and thus we made a comprehensive analysis of pain genes in the prognosis of KIRC and tumor immunotherapy.
Methods: In this study, TCGA, Kaplan-Meier plotter, Metascape, STRING, Human Protein Atlas, Single Cell Expression Atlas database, LinkedOmics, cBioPortal, MethSurv, CancerSEA, COSMIC database and R package (ggplot2, version 3.3.
Article Synopsis
- The study aims to improve the diagnosis and understanding of Medullary Sponge Kidney (MSK) by examining imaging features, clinical traits, and gene expression related to kidney development and immune response.
- The research involved analyzing data from 17 MSK patients, revealing that the condition affects both genders equally, predominantly occurs in individuals aged 31-50, and is frequently associated with nephrocalcinosis and nephrolithiasis.
- Key genes such as HNF1B, CLCN5, and GDNF have been identified as potential diagnostic indicators for MSK, with gene mutations contributing to abnormal kidney development as a primary cause of the disease.
To uncover advanced prognosis biomarkers in patient with kidney renal clear cell carcinoma (KIRC), our study was the first to make a comprehensive analysis of hsa-mir-21 predicted target genes and explore the immune characteristics in KIRC. In this study, the comprehensive analysis of hsa-mir-21 predicted target genes and immune characteristics in KIRC were analyzed via TIMER2.0, UALCAN, Metascape, Kaplan-Meier plotter, Human Protein Atlas, CancerSEA, JASPAR, GEPIA, R package: GSVA package (version 1.
View Article and Find Full Text PDFObjective: To uncover novel prognostic and therapeutic targets for BLCA, our study is the first to investigate the role of hsa-mir-183 and its up-regulated predicted target genes in bladder urothelial carcinoma.
Methods: To address this issue, our study explored the roles of hsa-mir-183 predicted target genes in the prognosis of BLCA via UALCAN, Metascape, Kaplan-Meier plotter, Human Protein Atlas, TIMER2.0, cBioPortal and Genomics of Drug Sensitivity in Cancer databases.
Article Synopsis
- The study aimed to explore immune profiles in patients with benign prostatic hyperplasia (BPH) by measuring lymphocyte subsets and T cell proportions.
- Results showed significant reductions in CD3, CD4, and CD8 T cells in BPH patients, while NK and B cells remained unchanged.
- The findings suggest that immune dysfunction related to BPH may increase the risk of infections and tumor development, potentially contributing to the progression towards prostate cancer.
Low-dose irradiation (LDI) has been used in clinics to treat human diseases, including chronic inflammation. This study assessed the effects of LDI on the inflammatory response of activated mouse primary peritoneal macrophages, and the underlying signal pathways. Primary peritoneal macrophages were isolated from mice and then incubated with lipopolysaccharide (LPS)-coated Ti microparticles (Ti-positive control) with or without brief exposure to LDI (X-ray, 0.
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