Quantitative Proteomics Provided Insights into the Protective Effects of Heat Acclimation on the Rat Hypothalamus after Exertional Heatstroke.

Background: The effects of heat acclimation (HA) on the hypothalamus after exertional heatstroke (EHS) and the specific mechanism have not been fully elucidated, and this study aimed to address these questions.

Methods: In the present study, rats were randomly assigned to the control, EHS, HA, or HA + EHS groups (n = 9). Hematoxylin and eosin (H&E) staining was used to examine pathology.

Modeling road user response timing in naturalistic traffic conflicts: A surprise-based framework.

There is currently no established method for evaluating human response timing across a range of naturalistic traffic conflict types. Traditional notions derived from controlled experiments, such as perception-response time, fail to account for the situation-dependency of human responses and offer no clear way to define the stimulus in many common traffic conflict scenarios. As a result, they are not well suited for application in naturalistic settings.

Research progress on carbon materials in tumor photothermal therapy.

At present, cancer remains one of the leading causes of human death worldwide, and surgery, radiotherapy and chemotherapy are still the main methods of cancer treatment. However, these treatments have their drawbacks. Surgical treatment often struggles with the complete removal of tumor tissue, leading to a high risk of cancer recurrence.

Management of regional citrate anticoagulation for continuous renal replacement therapy: guideline recommendations from Chinese emergency medical doctor consensus.

Continuous renal replacement therapy (CRRT) is widely used for treating critically-ill patients in the emergency department in China. Anticoagulant therapy is needed to prevent clotting in the extracorporeal circulation during CRRT. Regional citrate anticoagulation (RCA) has been shown to potentially be safer and more effective and is now recommended as the preferred anticoagulant method for CRRT.

Acquired heat acclimation in rats subjected to physical exercise under environmental heat stress alleviates brain injury caused by exertional heat stroke.

Exertional heatstroke (EHS) is an emergency with a high mortality rate, characterized by central nervous system dysfunctions. This study aims to establish a Heat acclimation/acclimatization (HA) rat model in locomotion to recapitulate the physical state of human in severe environment of high temperature and humidity, and investigate the mechanism of organism protection in HA. (2) Methods: Wistar rats were exposed to 36 °C and ran 2 h/d for 21 days, acquired thermal tolerance test was conducted to assess the thermotolerance and exercise ability.

Efficacy and safety of GLP-1 receptor agonists versus SGLT-2 inhibitors in overweight/obese patients with or without diabetes mellitus: a systematic review and network meta-analysis.

Objective: To compare the efficacy and safety between and within glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT-2is) in overweight or obese adults with or without diabetes mellitus.

Methods: PubMed, ISI Web of Science, Embase and Cochrane Central Register of Controlled Trials database were comprehensively searched to identify randomised controlled trials (RCTs) of effects of GLP-1RAs and SGLT-2is in overweight or obese participants from inception to 16 January 2022. The efficacy outcomes were the changes of body weight, glucose level and blood pressure.

Comparing Subjective Similarity of Automated Driving Styles to Objective Distance-Based Similarity.

Objective: This study explores subjective and objective driving style similarity to identify how similarity can be used to develop driver-compatible vehicle automation.

Background: Similarity in the ways that interaction partners perform tasks can be measured subjectively, through questionnaires, or objectively by characterizing each agent's actions. Although subjective measures have advantages in prediction, objective measures are more useful when operationalizing interventions based on these measures.

Photocatalytic degradation of tetracycline hydrochloride with g-CN/Ag/AgBr composites.

Graphite carbon nitride (g-CN), as a polymer semiconductor photocatalyst, is widely used in the treatment of photocatalytic environmental pollution. In this work, a Z-scheme g-CN/Ag/AgBr heterojunction photocatalyst was prepared based on the preparation of a g-CN-based heterojunction loading through photoreduction method. The g-CN/Ag/AgBr composite showed an excellent photocatalytic performance in the degradation of tetracycline hydrochloride pollutants.

First report of Phytophthora blight caused by Phytophthora nicotianae on Daphne odora in China.

The variegated leaves and fragrant flowers of Daphne odora var. marginata Mak. make it a popular garden plant.

NiFeO/g-CN heterostructure with an enhanced ability for photocatalytic degradation of tetracycline hydrochloride and antibacterial performance.

In this work, NiFeO/g-CN heterostructure was prepared and used for the photocatalytic decomposition of tetracycline hydrochloride antibiotic and for inactivation of E. coli bacteria. The fabricated NiFeO/g-CN composite displayed enhanced ability for photodegradation of organic pollutants and disinfection activities compared to the bare samples, because of the enhancement of visible light absorbance, heterojunction formation and photo-Fenton process.

Exertional rhabdomyolysis in newly enrolled cadets of a military academy.

Introduction/aims: Exertional rhabdomyolysis (ER) often occurs during prolonged intense exercise in hot environments, posing a threat to the health of military personnel. In this study we aimed to investigate possible risk factors for ER and provide further empirical data for prevention and clinical treatment strategies.

Methods: A retrospective investigation of 116 concurrent ER cases was conducted.

NiP/CuO composites: Electroless plating synthesis, antibiotic photodegradation and antibacterial properties.

This work reports a simple method to prepare nickel-phosphorus (Ni-P) alloy modified CuO (Ni-P/CuO) composite, which shows excellent performance in terms of photodegradation antibiotics, particularly regarding the antibacterial properties. The Ni-P/CuO composites were prepared via two steps. The first step was to produce CuO by the hydrothermal method and the second step was to grow Ni-P in-situ on the surface of CuO through electroless plating.

Interpretations and comments for expert consensus on the diagnosis and treatment of heat stroke in China.

Heat stroke is the most severe type of heat illness, it is often accompanied by severe multiorgan damage and has a high fatality rate. In January 2020, based on new research evidence and the experiences of Chinese experts in heat stroke, the Expert Group of Heat Stroke Prevention and Treatment of the Chinese People's Liberation Army (PLA) and the Professional Committee of Critical Care Medicine of the Chinese PLA jointly issued a new Expert Consensus on the Diagnosis and Treatment of Heat Stroke in China. This article aims to interpret and supplement the major updates to the new consensus.

The prognostic value of routine coagulation tests for patients with heat stroke.

Objective: To evaluate the prognostic value of routine coagulation tests for patients with heat stroke.

Methods: This was a multi-center retrospective study. Patients who arrived at the hospital <24 h after the onset of Heat Stroke (HS) were included.

T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019.

This study evaluated the significance of lymphocyte subset detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3+ T cells, CD4+ T cells, CD8+ T cells, and natural killer cells were significantly decreased in patients with COVID-19. These patients had a relatively slight decrease in CD4+ T cells but a severe decrease in CD8+ T cells.

Expert consensus on the diagnosis and treatment of thrombocytopenia in adult critical care patients in China.

Thrombocytopenia is a common complication of critical care patients. The rates of bleeding events and mortality are also significantly increased in critical care patients with thrombocytopenia. Therefore, the Critical Care Medicine Committee of Chinese People's Liberation Army (PLA) worked with Chinese Society of Laboratory Medicine, Chinese Medical Association to develop this consensus to provide guidance for clinical practice.

Accelerating Photocatalytic Hydrogen Production and Pollutant Degradation by Functionalizing g-CN With SnO.

Energy crises and environmental pollution are two serious threats to modern society. To overcome these problems, graphitic carbon nitride (g-CN) nanosheets were fabricated and functionalized with SnO nanoparticles to produce H from water splitting and degrade 2-chlorophenol under visible light irradiation. The fabricated samples showed enhanced photocatalytic activities for both H evolution and pollutant degradation as compared to bare g-CN and SnO.

Expert consensus on the diagnosis and treatment of heat stroke in China.

Heat stroke (HS) is a fatal disease caused by thermal damage in the body, and it has a very high mortality rate. In 2015, the People's Liberation Army Professional Committee of Critical Care Medicine published the first expert consensus on HS in China, Expert consensus on standardized diagnosis and treatment for heat stroke. With an increased understanding of HS and new issues that emerged during the HS treatment in China in recent years, the 2015 consensus no longer meet the requirements for HS prevention and treatment.

Assessing Drivers' Trust of Automated Vehicle Driving Styles With a Two-Part Mixed Model of Intervention Tendency and Magnitude.

Objective: This study examines how driving styles of fully automated vehicles affect drivers' trust using a statistical technique-the two-part mixed model-that considers the frequency and magnitude of drivers' interventions.

Background: Adoption of fully automated vehicles depends on how people accept and trust them, and the vehicle's driving style might have an important influence.

Method: A driving simulator experiment exposed participants to a fully automated vehicle with three driving styles (aggressive, moderate, and conservative) across four intersection types (with and without a stop sign and with and without crossing path traffic).

Conjugated Electron Donor⁻Acceptor Hybrid Polymeric Carbon Nitride as a Photocatalyst for CO Reduction.

This work incorporates a variety of conjugated donor-acceptor (DA) co-monomers such as 2,6-diaminopurine (DP) into the structure of a polymeric carbon nitride (PCN) backbone using a unique nanostructure co-polymerization strategy and examines its photocatalytic activity performance in the field of photocatalytic CO reduction to CO and H under visible light irradiation. The as-synthesized samples were successfully analyzed using different characterization methods to explain their electronic and optical properties, crystal phase, microstructure, and their morphology that influenced the performance due to the interactions between the PCN and the DPco-monomer. Based on the density functional theory (DFT) calculation result, pure PCN and CNU-DP trimers (interpreted as incorporation of the co-monomer at two different positions) were extensively evaluated and exhibited remarkable structural optimization without the inclusion of any symmetry constraints (the non-modified sample derived from urea, named as CNU), and their optical and electronic properties were also manipulated to control occupation of their respective highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO).

Ag Loading Enhanced Photocatalytic Activity of g-CN Porous Nanosheets for Decomposition of Organic Pollutants.

The g-CN porous nanosheets with different loading amount of Ag nanoparticles (NPs) are successfully prepared by a simple liquid-phase reduction method. These Ag/g-CN composites have an improved photocatalytic performance for decomposing organic pollutants compared with that of pure g-CN nanosheets. Many measurements have been used for characterizing the samples, such as XRD, FTIR, UV-Vis DRS, PL, XPS, EDS, SEM, and TEM.

Recyclable magnetic NiFeO/C yolk-shell nanospheres with excellent visible-light-Fenton degradation performance of tetracycline hydrochloride.

A photo-Fenton-like reaction was considered as an effective method for wastewater treatment because it could produce more oxidative species such as hydroxyl radicals (˙OH) to accelerate the reaction. In this paper, a NiFe2O4/C (abbr. as NFO/C) yolk-shell nanostructure was synthesized via one-step calcination using polyacrylic acid sodium salt (PAAS) NPs as a template.

The novel three-way variant t(6;17;15)(p21;q21;q22) in acute promyelocytic leukemia with an FLT3-ITD mutation: A case report.

Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17)(q22;q21), resulting in the fusion of the promyelocytic leukemia gene at 15q22 with the retinoic acid receptor α at 17q21. Additionally, all patients with APL who have additional chromosome abnormalities (ACA) and gene mutations are resistant to all-trans retinoic acid (ATRA), the drug that causes disease regression specifically in patients with APL globally. The present study describes a case of a 19-year-old female with APL carrying a novel complex variant translocation t(6;17;15)(p21;q21;q22), add(7)(q32) and an FMS-related tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation.

Comparison of fungal communities among ten macrophyte rhizospheres.

The fungal community composition, size and several physico-chemical properties were individually investigated in ten macrophyte rhizospheric substrates using nested PCR-denaturing gradient gel electrophoresis and soil chemical methods. Results indicated that both Dothideomycetes and Sordariomycetes were dominant fungi in macrophyte rhizospheric substrates, and denitrifying fungi (Fusarium graminearum) was found in nine of ten macrophyte rhizospheres. Fungal Shannon-Wiener diversity index (H) and richness (S) in Thalia dealbata, Typha latifolia, Iris hexagona and Hemerocallis aurantiaca rhizospheres were higher than those in other six rhizospheres.