Publications by authors named "Shu Ning Yan"
Glycosaminoglycan (GAG) molecules on the surface of red blood cells play an important regulatory role in the invasion of merozoites of apicomplexan protozoa. Heparan sulfate, a type of GAG molecule, has been identified as an important receptor facilitating the invasion of red blood cells by these parasites. Proteins in the parasite that exhibit strong affinity for heparin may play a pivotal role in this invasion process.
View Article and Find Full Text PDFRisk assessment of imported malaria in China: a machine learning perspective.
BMC Public Health
March 2024
Article Synopsis
- China's designation as malaria-free has led to increased concern about imported malaria cases affecting reestablishment; this study explores machine learning’s role in assessing these risks.
- Data on imported malaria cases from 2011 to 2019 was analyzed, using R for data processing and ArcGIS for visualization, resulting in a clean dataset of 765 entries from 85 countries.
- The Random Forest machine learning model outperformed others, with a 95.3% accuracy in predicting risks for 2019, highlighting its potential for effective risk assessment and control strategies for imported malaria in China.
The potential mechanism of Neu5Gc inducing colorectal cancer based on network pharmacology and experimental validation.
Naunyn Schmiedebergs Arch Pharmacol
April 2023
Colorectal cancer has high morbidity and mortality worldwide, especially in western countries; the incidence of colorectal cancer has been high, which is closely related to the high intake of red meat; and the N-glycolylneuraminic acid (Neu5Gc) is responsible for red meat-induced colorectal cancer. A large number of previous studies have suggested that exogenous Neu5Gc-activated inflammation induced the occurrence of colorectal cancer. However, it has not been known whether the Neu5Gc has a direct inducing effect on colorectal cancer.
View Article and Find Full Text PDF