Publications by authors named "Shu Jing Deng"
Background: The M1/M2 polarization of intestinal macrophages exerts an essential function in the pathogenesis of ulcerative colitis (UC), which can be adjusted to alleviate the UC symptoms.
Purpose: A kind of pH-sensitive lipid calcium phosphate core-shell nanoparticles (NPs), co-loading with dexamethasone (Dex) and its water-soluble salts, dexamethasone sodium phosphate (Dsp), was constructed to comprehensively regulate macrophages in different states towards the M2 phenotype to promote anti-inflammatory effects.
Methods: Dex and Dsp were loaded in the outer lipid shell and inner lipid calcium phosphate (Cap) core of the LCaP NPs, respectively.
Article Synopsis
- Long-term use of glucocorticoids (GCs) for treating ulcerative colitis (UC) can cause severe side effects; local administration via enema could concentrate GCs at the inflamed site but faces challenges due to short colonic residence time caused by diarrhea.
- To improve treatment efficacy, researchers developed mucoadhesive nanoparticles (NPs) that can attach to inflamed colonic tissue, enhancing the local concentration of dexamethasone derivatives (DDs) for better targeted therapy.
- In vivo tests on colitis mice showed that the synthesized nanoparticles had good stability, sustained release, and effectively improved UC symptoms, indicating potential benefits for patients.
Complete mitochondrial genome sequence of the blue sheep, Pseudois nayaur szechuanensis (Cetartiodactyla: Caprinae).
Mitochondrial DNA A DNA Mapp Seq Anal
October 2016
The blue sheep (Pseudois nayaur szechuanensis) belongs to the subfamily Caprinae, which distributes in Sichuan, Gansu, Qinghai, southeastern Xinjiang, northern Yunnan and Ningxia-Inner Mongolia border, China. In this study, the complete mitochondrial genome of P. n.
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