Publications by authors named "Shu Hui Thng"
Biotechnol Bioeng
December 2012
Article Synopsis
- Identifying the right mammalian cell lines, particularly CHO cells, is essential for efficient production of monoclonal antibodies (mAbs).
- This study uses metabolomics to compare metabolite profiles of eight CHO cell clones with varying mAb production rates, finding significant differences that correlate to their productivity.
- Seven key metabolites were identified, linked to critical cellular processes, suggesting that high-producing cell lines maintain better redox status and energy regulation to enhance mAb production.
