Long-Term efficacy and safety analysis of secukinumab in the treatment of pediatric generalized pustular psoriasis: a real-world study.

To evaluate the long-term efficacy and safety of secukinumab in pediatric patients with generalized pustular psoriasis (GPP). A retrospective study was conducted from July 2021 to July 2024, including 10 children with GPP. Patients were divided into two age groups: children aged 0-3 years received 75 mg of secukinumab, while those aged 3-12 years received 150 mg.

Multi-temporal image analysis of wetland dynamics using machine learning algorithms.

Wetlands play a crucial role in enhancing groundwater quality, mitigating natural hazards, controlling erosion, and providing essential habitats for unique flora and wildlife. Despite their significance, wetlands are facing decline in various global locations, underscoring the need for effective mapping, monitoring, and predictive modeling approaches. Recent advances in machine learning, time series earth observation data, and cloud computing have opened up new possibilities to address the challenges of large-scale wetlands mapping and dynamics forecasting.

Integrating multisource data and machine learning for supraglacial lake detection: Implications for environmental management and sustainable development goals in high mountainous regions.

The accurate detection and monitoring of supraglacial lakes in high mountainous regions are crucial for understanding their dynamic nature and implications for environmental management and sustainable development goals. In this study, we propose a novel approach that integrates multisource data and machine learning techniques for supra-glacial lake detection in the Passu Batura glacier of the Hunza Basin, Pakistan. We extract pertinent features or parameters by leveraging multisource datasets such as radar backscatter intensity VH and VV parameters from Sentinel-1 Ground Range Detected (GRD) data, near-infrared (NIR), NDWI_green, NDWI_blue parameters from Sentinel-2 Multi-spectral Instrument (MSI) data, and surface slope, aspect, and elevation parameters from topographic data.

Ultrasound-mediated nanobubbles loaded with STAT6 siRNA inhibit TGF-β1-EMT axis in LUSC cells via overcoming the polarization of M2-TAMs.

M2-like tumor-associated macrophages (M2-TAMs) are closely correlated with metastasis and poor clinical outcomes in lung squamous cell carcinoma (LUSC). Previous studies have demonstrated that STAT6 is an important signaling molecule involved in the polarization of M2-TAMs, EMT is the main way for TAMs to promote tumor progression. However, little attention has been paid to the effect of STAT6 inhibition on LUSC, and it is difficult to achieve an ideal gene silencing effect in immune cells using traditional gene transfection methods.

Diagnostic, prognostic, and immunological roles of CDSN in ovarian cancer.

Globally, ovarian cancer (OC) ranks as a principal cause of cancer-related mortality in females. Immunotherapy has revolutionized the treatment of OC, but the efficacy of immunotherapy is often limited by different immune microenvironments. The objective of this research was to pinpoint and validate candidate genes with potential value as diagnostic and prognostic biomarkers and therapeutic targets in OC.

Glyco-signatures in patients with advanced lung cancer during anti-PD-1/PD-L1 immunotherapy.

Immune checkpoint inhibitors (ICIs) targeting programmed cell death 1/programmed cell death ligand-1 (PD-1/PD-L1) have significantly prolonged the survival of advanced/metastatic patients with lung cancer. However, only a small proportion of patients can benefit from ICIs, and clinical management of the treatment process remains challenging. Glycosylation has added a new dimension to advance our understanding of tumor immunity and immunotherapy.

Quantifying the scale of erosion along major coastal aquifers of Pakistan using geospatial and machine learning approaches.

Insufficient freshwater recharge and climate change resulted in seawater intrusion in most of the coastal aquifers in Pakistan. Coastal aquifers represent diverse landcover types with varying spectral properties, making it challenging to extract information about their state hence, such investigation requires a combination of geospatial tools. This study aims to monitor erosion along the major coastal aquifers of Pakistan and propose an approach that combines data fusion into the machine and deep learning image segmentation architectures for the erosion and accretion assessment in seascapes.

Development of a Reliable GADSAH Model for Differentiating AFP-negative Hepatic Benign and Malignant Occupying Lesions.

Purpose: Developing a high-value, convenient, and validated differential diagnosis model to differentiate alpha-fetoprotein (AFP) negative hepatic occupying lesions and assist clinicians in early identification and intervention.

Patients And Methods: A total of 340 patients with AFP-negative hepatic occupying lesions who were admitted to the Guangxi Medical University Cancer Hospital between August 2021 and April 2023 were included in the final retrospective analysis. The data were randomly divided into training and validation sets in a 7:3 ratio after performing multiple interpolations.

Nomogram for Predicting Postoperative Pulmonary Metastasis in Hepatocellular Carcinoma Based on Inflammatory Markers.

Background: Uncertainty surrounds the usefulness of inflammatory markers in hepatocellular carcinoma (HCC) patients for predicting postoperative pulmonary metastasis (PM). The purpose of this study was to assess the predictive value of inflammatory markers as well as to create a new nomogram model for predicting PM.

Methods: Cox regression was utilized to identify independent prognostic variables and to create a nomogram that predicted PM for comparison with a validation cohort and other prediction systems.

High-Strength, High-Swelling-Resistant, High-Sensitivity Hydrogel Sensor Prepared with Wood That Retains Lignin.

Wood-derived hydrogels possess satisfactory longitudinal strength but lack excellent swelling resistance and dry shrinkage resistance when achieving high anisotropy. In this study, we displayed the preparation of highly dimensional stable wood/polyacrylamide hydrogels (wood/PAM-Al). The alkali-treated wood retains lignin as the skeleton of the hydrogel.

Generalized granuloma annulare in an infant clinically manifested as papules and atrophic macules: A case report.

Background: Granuloma annulare (GA) has diverse clinical manifestations including papules, plaques, and nodules on the extremities that are skin-colored, pink, or purple. Approximately 15% of all GA cases are considered generalized GA.

Case Summary: Herein, we describe the case of a pediatric patient who initially presented with papules and later developed generalized atrophic macules.

Lactic acid sting test and capsaicin test differentially induce facial erythematous reaction in subjects with sensitive skin.

Background: Sensitivity skin (SS) is a common skin disorders, which have a various of clinical manifestation. Facial erythema is common objective symptom of SS. However, the reasons for the occurrence of erythema in sensitive skin are not fully understood.

[Diagnostic value and interventional treatment of elbow cyst by high frequency ultrasound].

Objective: To study and analyze the diagnostic value and interventional treatment value of high-frequency ultrasound for elbow cyst.

Methods: From February 2018 to February 2021, the data of 60 patients with elbow cyst treated by high-frequency ultrasound interventional therapy were retrospectively analyzed, including 30 males and 30 females with an average age of (30.93±5.

Novel Long Noncoding RNAs, and , Serve as Potential Diagnostic and Prognostic Biomarkers or Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is one of the most fatal human malignancies worldwide. In this research, we aimed to identify long noncoding RNAs (lncRNAs) as biomarkers for HCC diagnosis and prognosis. lncRNA expression profiles were obtained from Gene Expression Omnibus and The Cancer Genome Atlas databases.

Ultrasound-mediated PLGA-PEI Nanobubbles Carrying STAT6 SiRNA Enhances NSCLC Treatment Repolarizing Tumor-associated Macrophages from M2 to M1 Phenotypes.

Background: Tumor-associated macrophages (TAMs) are crucial for non-small cell lung cancer (NSCLC) development.

Objective: In this study, polylactic acid-co-glycolic acid (PLGA)-polyethylenimine (PEI) nanobubbles (NBs) carrying STAT6 siRNA were prepared and combined with ultrasound-mediated nanobubbles destruction (UMND) to silence the STAT6 gene, ultimately repolarizing TAMs from the M2 to the M1 phenotype, treating NSCLC .

Methods: PLGA-PEI NBs-siRNA were prepared and characterised, and their respective ultrasound imaging, biological stabilities and cytotoxicities were detected.

Study on the effect of fluorinated solvent electrolyte on the active material and cycle performance of a commercial 21700-type battery.

Different electrolyte schemes were studied on the traditional commercial 21700-type battery. The effect of different fluorinated electrolytes on the cycle performance of the battery was systematically investigated. When methyl (2,2,2-trifluoroetyl) carbonate (FEMC) was introduced, due to the low conductivity of FEMC, the polarization and internal resistance of the battery increased, which leads to the increase of constant voltage charging time, leading to the cracking of the cathode material and reduction of the cycle performance.

Elastic fiber degradation in the development of pediatric granuloma annulare: Report of 39 cases.

Background: Granuloma annulare (GA) has diverse clinical manifestations, multiple subtypes, and unknown etiology and pathogenesis. Existing studies regarding GA in children are scarce.

Aim: To examine the correlation between clinical manifestation and histopathology of pediatric GA.

Insight into the role of PCSK9 in glucose metabolism.

Diabetes mellitus (DM) is strongly associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD). Proprotein convertase subtilisin/kexin type 9 (PCSK9) was recently identified as an important regulator of circulating low-density lipoprotein-cholesterol (LDL-C) levels via degradation of the LDL receptor, proving to be a valid target to improve lipoprotein profiles and cardiovascular outcomes in patients with ASCVD. Beyond LDL receptor processing and cholesterol homeostasis, the PCSK9 protein has recently been verified to be associated with glucose metabolism.

Identification of time-varying wetlands neglected in Pakistan through remote sensing techniques.

Aside from Ramsar Convention awareness programs, the concept of wetlands is mostly ignored in developing countries. Wetland ecosystems are essential to hydrological cycles, ecosystem diversity, climatic change, and economic activity. Under the Ramsar Convention, there are 2414 wetlands that are internationally recognized, and Pakistan is home to 19 of them.

Sinking delta: Quantifying the impacts of saltwater intrusion in the Indus Delta of Pakistan.

This study focused on an integrated assessment of coastline change and its impacts on the deltaic sustainability of the Indus Delta, the world's fifth-largest delta. The increase in salinity and degradation of mangrove habitat was examined using multi-temporal Landsat satellite imagery from 1990 to 2020. The tasselled cap transformation indices, multi-statistical End Point Rate and Linear Regression were used to extract the shorelines rates.

Land subsidence analysis using synthetic aperture radar data.

Land subsidence is considered a threat to developing cities and is triggered by several natural (geological and seismic) and human (mining, groundwater withdrawal, oil and gas extraction, constructions) factors. This research has gathered datasets consisting of 80 Sentinel-1A ascending and descending SLC images from July 2017 to July 2019. This dataset, concerning InSAR and PS-InSAR, is processed with SARPROZ software to determine the land subsidence in Gwadar City, Balochistan, Pakistan.

Nascent Proteome and Glycoproteome Reveal the Inhibition Role of ALG1 in Hepatocellular Carcinoma Cell Migration.

Unlabelled: Asparagine-linked glycosylation protein 1 homolog (ALG1) participates in the initial stage of protein -glycosylation and -glycosylation has been implicated in the process of hepatocellular carcinoma (HCC) progression. However, whether ALG1 plays a role in human HCC remains unknown. In this study, the expression profile of ALG1 in tumorous and corresponding adjacent non-tumor tissues was analyzed.