Cationic Modification in Hybrid Iodates: A Pathway to Superior Performance.

The utilization of nonlinear optical (NLO) crystals plays a crucial role in the contemporary laser industry, and the advancement of novel NLO-active units is essential for the exploration of NLO materials. Two novel organic-inorganic hybrid iodates, designated as (CNH)MoO(IO)·3HO () and (CNIH)MoO(IO)·4HO () were synthesized via mild hydrothermal methods, exhibiting band gaps of 3.75 and 3.

Engineering of a hydroxysteroid dehydrogenase with simultaneous enhancement in activity and thermostability for efficient biosynthesis of ursodeoxycholic acid.

Unlabelled: Hydroxysteroid dehydrogenases (HSDHs) catalyze the oxidation/reduction of hydroxyl/keto groups of steroids with high regio- or stereoselectivity, playing an essential role in producing optically pure chemicals. In this work, a novel approach was developed to simultaneously improve the stability and activity of 7β-hydroxysteroid dehydrogenase (7β-HSDH) by combining B-factor analysis and computer-aided prediction. Several advantageous mutants were identified, and the most promising variant, S51Y/P202Y, exhibited 2.

Development of quercetin-loaded electrospun nanofibers through shellac coating on gelatin: Characterization, colon-targeted delivery, and anticancer activity.

Quercetin possesses multiple biological activities. To achieve efficient colon-specific release of quercetin, new composite nanofibers were developed by coating pH-responsive shellac on hydrophilic gelatin through coaxial electrospinning. These composite nanofibers contained bead-like structures.

Efferocytosis: Unveiling its potential in autoimmune disease and treatment strategies.

Efferocytosis is a crucial process whereby phagocytes engulf and eliminate apoptotic cells (ACs). This intricate process can be categorized into four steps: (1) ACs release "find me" signals to attract phagocytes, (2) phagocytosis is directed by "eat me" signals emitted by ACs, (3) phagocytes engulf and internalize ACs, and (4) degradation of ACs occurs. Maintaining immune homeostasis heavily relies on the efficient clearance of ACs, which eliminates self-antigens and facilitates the generation of anti-inflammatory and immunosuppressive signals that maintain immune tolerance.

Advances in aldo-keto reductases immobilization for biocatalytic synthesis of chiral alcohols.

Chiral alcohols are essential building blocks of numerous pharmaceuticals and fine chemicals. Aldo-keto reductases (AKRs) constitute a superfamily of oxidoreductases that catalyze the reduction of aldehydes and ketones to their corresponding alcohols using NAD(P)H as a coenzyme. Knowledge about the crucial roles of AKRs immobilization in the biocatalytic synthesis of chiral alcohols is expanding.

(CHNO)(HSO): A Cytosinium Bisulfate with Large Birefringence and Moderate Second Harmonic Generation Effect Produced via Combining a Promising Planar Nonlinear Optical-Active Motif with a Tetrahedral Group.

Investigating novel nonlinear optical (NLO) active units serves as a valuable method for broadening the research landscape of NLO materials. This study showcases the potential of the cytosinium cation (CHNO) as a novel NLO-active motif through theoretical calculations. The title compound exhibited a wide band gap of 3.

AntDAS-GCMS: A New Comprehensive Data Analysis Platform for GC-MS-Based Untargeted Metabolomics with the Advantage of Addressing the Time Shift Problem.

Over the years, a number of state-of-the-art data analysis tools have been developed to provide a comprehensive analysis of data collected from gas chromatography-mass spectrometry (GC-MS). Unfortunately, the time shift problem remains unsolved in these tools. Here, we developed a novel comprehensive data analysis strategy for GC-MS-based untargeted metabolomics (AntDAS-GCMS) to perform total ion chromatogram peak detection, peak resolution, time shift correction, component registration, statistical analysis, and compound identification.

Bispectral Index Monitoring in the Nursing of Patients With Paroxysmal Sympathetic Hyperactivity.

Aim: To investigate the clinical nursing effect of bispectral index (BIS) monitoring for paroxysmal sympathetic hyperactivity (PSH) patients in the neurosurgical intensive care unit (NICU).

Methods: From January 2022 to June 2023, a total of 30 patients with PSH secondary to moderate to severe craniocerebral injury in the NICU were monitored for BIS. The patients' paroxysmal sympathetic hyperactivity-assessment measure (PSH-AM) scores were recorded.

Fabrication and characterization of shellac nanofibers with colon-targeted delivery of quercetin and its anticancer activity.

In this study, the feasibility of shellac nanofibers as carrier system for colonic delivery of quercetin was evaluated. Firstly, the nanofibers without and with different amounts (2.5 %, 5.

[C(NH)][B(COH)]: An Organic-Inorganic Hybrid Borate Containing Nonlinear-Optical Active Unit [B(COH)] with Solar-Blind-Region Optical Nonlinearity.

We herein report an unprecedented organic-inorganic hybrid borate incorporating a novel nonlinear-optical (NLO) active unit, namely, [C(NH)][B(COH)]. The novel NLO active unit was derived from the condensation reaction between two glycol molecules and one (BO) group. The title compound exhibits a moderate second-harmonic-generation effect (0.

[C(NH)]MoO: A Guanidinium Molybdate as a UV Nonlinear Optical Crystal with Large Birefringence.

The key to searching novel nonlinear optical (NLO) crystals was effectively combining the NLO-active units to obtain a noncentrosymmetric structure. Nevertheless, the present predicament lies in the growing challenge of discovering novel crystals within conventional inorganic frameworks that surpass the properties of the current NLO materials. In view of this, researchers expanded their research focus to the organic-inorganic hybridization system; it is foreseeable to concentrate the advantages from several kinds of NLO-active units to acquire novel NLO crystals with superior properties.

Fabrication of colon-targeted ethyl cellulose/gelatin hybrid nanofibers: Regulation of quercetin release and its anticancer activity.

A colon-targeted delivery system that can efficiently deliver and release quercetin is essential to improve its bioavailability. We previously found that hydrophobic ethyl cellulose (EC) nanofibers could efficiently deliver quercetin to colon, but the release of quercetin was limited. To address this problem, hydrophilic gelatin (GN) was used as a regulator, and quercetin-loaded nanofibers with different mass ratios of EC to GN (3:1, 1:1, 1:2, 1:3) were fabricated by electrospinning.

Encapsulation of quercetin into zein-ethyl cellulose coaxial nanofibers: Preparation, characterization and its anticancer activity.

In order to efficiently improve the colon-targeted delivery of quercetin, the hydrophobic core-shell nanofibers were fabricated to encapsulate quercetin using ethyl cellulose as the shell and zein as the core by coaxial electrospinning. The encapsulation efficiency of coaxial nanofibers reached >97 %. FTIR and XRD results revealed the interactions between quercetin and wall materials and quercetin was encapsulated in an amorphous state.

Regulating the Electronic Structure of Ruddlesden-Popper-Type Perovskite by Chlorine Doping for Enhanced Oxygen Evolution Activity.

Developing economical, efficient, and durable oxygen evolution catalysts is crucial for achieving sustainable energy conversion and storage. Ruddlesden-Popper-type perovskite oxides are at the forefront of oxygen evolution reaction (OER) research. However, their activity and stability are far from satisfactory.

Cationic Defect Engineering in Perovskite LaCoMnO for Enhanced Electrocatalytic Oxygen Evolution.

The urgent need to promote the development of sustainable energy conversion requires exploration of highly efficient oxygen evolution reaction (OER) electrocatalysts. Defect engineering is a promising approach to address the inherent low electrical conductivity of metal oxides and limited reaction sites, for use in clean air applications and as electrochemical energy-storage electrocatalysts. In this article, oxygen defects are introduced into LaCoMnO perovskite oxides through the A-site cation defect strategy.

Tellurium-induced defect engineering for boosting the oxygen evolution reaction of spinel oxide.

Here, we report the successful synthesis of spinel oxides Te-NiCoO ( = 0, 2%, 4%, 6%) with different amounts of heteroatom Te doped in. Among them, 4%Te-NiCoO exhibits the best catalytic activity. Experimental results show that the incorporation of metalloid Te atoms into NiCoO facilitates the change of the electronic structure accompanied by the movement of the d-band center and produces more oxygen defects, which is beneficial for the improved OER activity of NiCoO.

[C(NH)NHNO][C(NH)](NO): A Mixed Organic Cationic Hybrid Nitrate with an Unprecedented Nonlinear-Optical-Active Unit.

We herein report a mixed organic cationic hybrid nitrate, namely, [C(NH)NHNO][C(NH)](NO) (). It was successfully achieved via combining three different planar groups: [(C(NH)NHNO], C(NH), and NO. First-principles calculations confirm that the [(C(NH)NHNO] group is an excellent cationic nonlinear-optical (NLO)-active unit.

Facile surface defect engineering on perovskite oxides for enhanced OER performance.

Perovskite oxides have been considered as potential alternative electrocatalysts in the oxygen evolution reaction (OER) field. In this work, a sequence of excellent OER perovskite catalysts was obtained by immersing SrCoFeO in a diluted HNO solution. Therein, the 24 h etched SrCoFeO sample (SCFO-24) exhibits the best OER activity, with an overpotential of 300 mV at 10 mA cm and a Tafel slope of 59.

Coevolving stability and activity of LsCR by a single point mutation and constructing neat substrate bioreaction system.

Carbonyl reductase (CR)-catalyzed bioreduction in the organic phase and the neat substrate reaction system is a lasting challenge, placing higher requirements on the performance of enzymes. Protein engineering is an effective method to enhance the properties of enzymes for industrial applications. In the present work, a single point mutation E145A on our previously constructed CR mutant LsCR , coevolved thermostability, and activity.

C(NH)(IO)(HIO)(HIO)(HIO)·3HO: An Unprecedented Asymmetric Guanidinium Polyiodate with a Strong Second-Harmonic-Generation Response and a Wide Band Gap.

Herein, we report an unprecedented asymmetric guanidinium polyiodate, namely, C(NH)(IO)(HIO)(HIO)(HIO)·3HO (). The title compound was obtained via the hybridization of polyiodate anions and planar π-conjugated C(NH); meanwhile, its strong second-harmonic-generation (SHG) response (2.1 × KDP, where KDP = KHPO) and wide band gap (3.

AntDAS-DDA: A New Platform for Data-Dependent Acquisition Mode-Based Untargeted Metabolomic Profiling Analysis with Advantage of Recognizing Insource Fragment Ions to Improve Compound Identification.

Data-dependent acquisition (DDA) mode in ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) can provide massive amounts of MS and MS/MS information of compounds in untargeted metabolomics and can thus facilitate compound identification greatly. In this work, we developed a new platform called AntDAS-DDA for the automatic processing of UHPLC-HRMS data sets acquired under the DDA mode. Several algorithms, including extracted ion chromatogram extraction, feature extraction, MS/MS spectrum construction, fragment ion identification, and MS spectrum construction, were developed within the platform.