Publications by authors named "Shu Cheng Jin"
Nat Biomed Eng
December 2024
Article Synopsis
- Immune rejection due to mismatched human leucocyte antigens (HLAs) poses a significant challenge for allogeneic cell therapies.
- Current methods to create 'universal' immune-compatible cells can lead to problems like genomic instability or cell damage.
- By targeting a specific super-enhancer linked to HLA-I expression in mesenchymal stromal cells, researchers were able to reduce HLA-I on the cell surface, enhancing their survival in a humanized mouse model and improving therapeutic outcomes in acute lung injury.
