Structural Variability, Expression Profile, and Pharmacogenetic Properties of TMPRSS2 Gene as a Potential Target for COVID-19 Therapy.

The human serine protease serine 2 TMPRSS2 is involved in the priming of proteins of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and represents a possible target for COVID-19 therapy. The TMPRSS2 gene may be co-expressed with SARS-CoV-2 cell receptor genes angiotensin-converting enzyme 2 (ACE2) and Basigin (BSG), but only TMPRSS2 demonstrates tissue-specific expression in alveolar cells according to single-cell RNA sequencing data. Our analysis of the structural variability of the TMPRSS2 gene based on genome-wide data from 76 human populations demonstrates that a functionally significant missense mutation in exon 6/7 in the TMPRSS2 gene is found in many human populations at relatively high frequencies, with region-specific distribution patterns.

Peptic Ulcer Disease and Helicobacter pylori Infection in Different Siberian Ethnicities.

Background: The high prevalence of Helicobacter pylori (H. pylori) infection in eastern Siberia is consistently established. In the same geographic area, however, fragmentary information is available on the epidemiology of the peptic ulcer disease (PUD).

Parameters of proliferation and apoptosis of epithelial cells in the gastric mucosa in indigenous and non-indigenous residents of Khakassia with Helicobacter pylori positive duodenal ulcer disease.

We evaluated parameters of apoptosis in the mucosa of the gastric antrum and body of indigenous and non-indigenous residents of Khakassia with duodenal ulcer disease associated with Helicobacter pylori infection. In the gastric antrum, apoptotic index was significantly increased in patients with ulcer disease in comparison with healthy individuals in both populations. The ratio of proliferation index to apoptotic index was lower in patients with ulcer disease in comparison with healthy individuals in both populations.

[The prevalence and clinical aspects of Barrett's esophagus in the population of Eastern Siberia].

Aim: To study the prevalence and clinical aspects of Barrett's esophagus (BE) in natives and newcomers in East Siberia.

Subjects And Methods: Clinical examinations and esophagogastroduodenoscopy were performed in 12975 Caucasoids and 1489 Khakases in Abakan (Khakasia), 1861 Caucasoids and 5829 Tuvinians in Kyzyl (Republic of Tuva), and 1177 Caucasoids in Dudinka (Taimyr). The diagnosis of BE was verified by morphological study.

[Peculiarities of relationship between atrophic gastritis and stomach cancer in the population of Eastern Siberia].

The authors studied the prevalence of atrophic gastritis, H.pylori strains carrying the CagA gene, seeding and apoptosis indices of gastric mucosa in indigenous and newcomer residents of Evenkia. A total of 136 Evenks and 159 newcomers were examined using fibrogastroscopy and biopsy of antral gastric mucosa.

[Genetic diversity of Khakassian gene pool: subethnic differensiation and the structure of Y-chromosome haplogroups,].

The structure of Khakass gene pool has been investigated: compositions and frequencies of Y-chromosome haplogroups were described in seven population samples of two basic subethnic groups--Sagays and Kachins from three territorially distanced regions of Khakassia Republic. Eight haplogroups: C3, E, N*, N1b, N1c, R1a1a and R1b1b1 have been determined in Khakass gene pool. Significant differences between Sagays and Kachins were shown in haplogroup spectra and a level of genetic diversity in haplogroups and YSTR-haplotypes.

[Population association features of interleukine gene polymorphism in khakases with gastroduodenal diseases].

Aim: To investigate association of polymorphisms of IL-1 genes and antagonist of IL-2 receptor (IL1Ra).

Material And Methods: Patients with chronic gastritis and ulcer were examined using the method of restriction analysis.

Results: It was found that CCILbeta and R4/R4IL1Ra are most prevalent allel variants in khakas population.

Characteristics of Populations of the Russian Federation over the Panel of Fifteen Loci Used for DNA Identification and in Forensic Medical Examination.

Seventeen population groups within the Russian Federation were characterized for the first time using a panel of 15 genetic markers that are used for DNA identification and in forensic medical examinations. The degree of polymorphism and population diversity of microsatellite loci within the Power Plex system (Promega) in Russian populations; the distribution of alleles and genotypes within the populations of six cities and 11 ethnic groups of the Russian Federation; the levels of intra- and interpopulation genetic differentiation of population; genetic relations between populations; and the identification and forensic medical characteristics of the system of markers under study were determined. Significant differences were revealed between the Russian populations and the U.

Helicobacter pylori Infection, Intestinal Metaplasia, and Gastric Cancer Risk in Eastern Siberia.

Background: The incidence of gastric cancer (GC) is extremely high in Russia and eastern Siberia, where information on the epidemiology of Helicobacter pylori infection is fragmentary.

Aims: To assess the prevalence of both H. pylori infection (including CagA status) and intestinal metaplasia (IM) in Russian and eastern Siberian populations carrying a different risk of GC.

[Prevalence of Helicobacter pylori CaGa strains and peptic ulcer in the population of Eastern Siberia].

Aim: To study prevalence of Helicobacter pylori (Hp) CagA strains and ulcer disease in native population of eastern Siberia and migrants.

Material And Methods: Epidemiological screening of Hp CagA strains and ulcer disease was performed by cross-sectional method in population of Evenkia, Khakassia, Tuva. Fibrogastroduodenoscopy was made in 3602 examinees; IgG of CagA Hp was detected in the sera of 2472 patients with entyme immunoassay.

[Features of the association of Helicobacter pylori infection and ulcer in Europeans and Mongoloids in Siberia].

Aim: To study association between Helicobacter Pylori infection in ulcer in native population and migrants in Siberia.

Materials And Methods: Epidemiological survey of ulcer has been performed in Northern (Evenkia, Yakutia) and Southern (Khakasia) regions of Siberia. Clinical examination covered 3908 Europeoids (Russians, Ukrainians) and 1999 Mongoloids (Evenks, Evens, Khakases).

[Helicobacter pylori and peptic ulcer in the population of Khakasiia].

Aim: To investigate the relationship between Helicobacter pylori infection and ulcer in population of Khakasiia.

Materials And Methods: An epidemiological study of dyspepsia and ulcer prevalence in Khakasiia population covered 1052 patients (564 residents and 488 immigrants). 339 patients were examined endoscopically.