Publications by authors named "Shruti Attreya"
Nat Microbiol
August 2024
Article Synopsis
- Delivering large therapeutic proteins effectively across biological barriers like the blood-brain barrier is challenging, but Toxoplasma gondii, a parasite, shows promise in overcoming this issue by naturally moving from the gut to the central nervous system.
- Researchers have engineered T. gondii's secretion systems to facilitate the delivery of these proteins into neurons, testing their effectiveness in lab cultures, brain organoids, and living mice.
- The study specifically highlights the successful delivery of the MeCP2 protein, which could be a potential treatment for Rett syndrome, while also discussing the system's limitations and potential for future improvements.
