Differential toxicity of cytosine arabinoside to cell kinetics in normal sheep sinus cells and sheep tumour cell line in vitro.

The effects of 1-beta-d-arabinofuranosylcytosine (ara-c) on cell proliferation, morphology and cycle progression were compared in a sheep tumour cell line and normal sheep sinus cells. The effects were found to be dose and time dependent and reversible, and were accompanied by increased cell size and cytosolic synthetic activities. Ara-c induced a concentration-dependent inhibition of cell proliferation in both normal and tumour cells.

Extraosseous giant cell tumour of lung.

A rare case of Extraosseous Osteoclastoma like giant cell tumour of the lung is presented.

Aggregative Escherichia coli, Salmonella, and Shigella are associated with increasing duration of diarrhea.

In order to relate etiology of diarrhea to the duration of the episode, a cohort of 452 children up to 36 months of age was visited once weekly at their households for 18 consecutive months to record diarrheal morbidity. Fecal specimens were obtained in 453 diarrheal episodes occurring in 354 children during this period. The common putative agents as single isolations associated with diarrhea were EA-AggEC (17.

Establishment, identification and characterization of a new sheep sinus tumor cell line.

A cell line designated SRT was established from a sheep sinus tumor. Following primary culture, the cells were serially passaged 40 times. SRT cells maintained an epithelioid fibroblast-like appearance and had a population doubling time of approximately 18 hr.

Pituitary-adrenocortical hyperfunction and intolerance to fluvoxamine, a selective serotonin uptake inhibitor.

Of nine nonsuppressors on the dexamethasone suppression test (DST), five (56%) developed intolerable side effects during treatment with fluvoxamine, a new serotonin uptake inhibiting antidepressant, compared with three of 24 suppressors (13%).

Dissolution dialysis studies of metronidazole-montmorillonite adsorbates.

In the context of the potential usefulness of clays in retarding the rate of release of adsorbed drugs, dissolution dialysis studies of the release of metronidazole from montmorillonite adsorbates have been conducted. The goal was to develop a means for improving local gastrointestinal therapy of amebiasis while concurrently maintaining efficacy in treating hepatic amebiasis. At acidic pH, the clay was in a flocculated state and the rate of drug release was inhibited.

Doxepin therapy for duodenal ulcer: a controlled trial in patients who failed to respond to cimetidine.

Ten patients with endoscopically proven active duodenal ulcers completed a double-blind placebo-controlled trial of doxepin hydrochloride. All ten had previously failed to respond to conventional cimetidine therapy. Doxepin was given at bedtime in a single 50-mg dose for the first week and, if needed, in a single 75-mg or 100-mg dose for the remainder of the six-week trial.

Doxepin and cimetidine in the treatment of duodenal ulcer: a double-blind comparative study.

Twenty-one patients with endoscopically proven active duodenal ulcers were studied in a double-blind randomized trial comparing doxepin hydrochloride (50 mg during the first week, and 100 mg thereafter, at bedtime) and cimetidine (1,200 mg/day in four divided doses). After two weeks, the average size of the ulcers had decreased 94% in the doxepin group (n = 8) versus 66% in the cimetidine group (n = 13) (P less than 0.01).

Comparative efficacy of some benzimidazoles and amoscanate (Go.9333) against experimental filarial infections.

The comparative efficacy of mebendazole, fenbendazole, oxibendazole, oxfendazole, albendazole, flubendazole and micronized amoscanate (particle size 5-8 micron) against Litomosoides carinii and Brugia pahangi infections in Mastomys natalensis was studied on administration of the compounds per os (150 mg/kg/day for 5 days) and subcutaneous (100 mg/kg/day for 5 days) routes. It was found that benzimidazoles when given by the oral route had no effect on adults of L. carinii and B.

A double-blind placebo-controlled study of fluvoxamine and imipramine in out-patients with primary depression.

1 A double-blind placebo-controlled study of fluvoxamine and imipramine was performed in a group of depressed patients. Twenty-two patients received fluvoxamine (mean dose 101 mg/day), 25 received imipramine (mean dose 127 mg/day) and 22 received placebo. 2 Apart from an increase in the SGOT and SGPT values of four imipramine patients, no statistically significant changes in haematology or urinalysis were judged to be medically relevant.

Non-specific antiviral activity of bovine leukocytes against infectious bovine rhinotracheitis virus in vitro.

Leukocytes collected from bovine blood inhibit the multiplication of virus in IBR infected MDBK cells. This inhibition is non-specific and can be observed in the absence of serum. Number of infected cells, number of leukocytes per infected cell and time of placing of leukocytes onto infected cells are some of the important factors in this protection.