Maresin-like 1 Ameliorates Neuropathology of Alzheimer's Disease in Brains of a Transgenic Mouse Model.

(1) Background: Impeded resolution of inflammation contributes substantially to the pathogenesis of Alzheimer's disease (AD); consequently, resolving inflammation is pivotal to the amelioration of AD pathology. This can potentially be achieved by the treatment with specialized pro-resolving lipid mediators (SPMs), which should resolve neuroinflammation in brains. (2) Methods: Here, we report the histological effects of long-term treatment with an SPM, maresin-like 1 (MarL1), on AD pathogenesis in a transgenic 5xFAD mouse model.

Utilizing Auricular Composite Grafts for Reconstruction of Nasal Ala Defects in Fitzpatrick Type III-V Indian Noses: Techniques and Outcomes.

Background: Nasal ala defects present significant reconstructive challenges due to their complex anatomy and functional importance. Auricular composite grafts, incorporating both skin and cartilage, are particularly suited for this purpose because they can replace the multilayered structure of the nasal ala in a single surgical procedure, thereby restoring both form and function. Clinical outcomes of these grafts in the reconstruction of ala defects have been highly promising with studies indicating near complete survival rates.

Reconstructing the population history of the Nicobarese.

The Nicobarese are the major tribal groups in the Nicobar district, situated south of the Andaman group of Islands. Linguistic phylogeny suggests that the linguistic ancestors of the Nicobarese settled the Nicobar archipelago in the early Holocene. So far, genetic research on them is low-resolution and restricted to the haploid DNA markers.

Microarray integrated spatial transcriptomics (MIST) for affordable and robust digital pathology.

10X Visium, a popular Spatial transcriptomics (ST) method, faces limited adoption due to its high cost and restricted sample usage per slide. To address these issues, we propose Microarray Integrated Spatial Transcriptomics (MIST), combining conventional tissue microarray (TMA) with Visium, using laser-cutting and 3D printing to enhance slide throughput. Our design facilitates independent replication and customization in individual labs to suit specific experimental needs.

A Facile and Efficient Synthesis of BODIPY-Based Fluorescent Probes for Selective Detection of Hydrazine.

A facile and ratiometric BODIPY-based fluorescent probe 4 was developed for the selective detection of hydrazine in solution phase. The BODIPY-based fluorophores 3 and 4 were easily prepared in high yields from the L-proline catalyzed reaction between α/β-formyl BODIPY 1 a/1 b and 3-cyanoacetylindole 2. Use of easily accessible substrates, benign solvent, catalytic amount of L-proline and high product yields are the advantageous features of the developed protocol.

Design and development of a mobile health intervention for rehabilitation support after knee arthroplasty: TeleRehabilitation after knee ArThroplasty (TReAT) project.

Background: The steep increase in knee arthroplasties in lower- and middle-income countries has increased demand for personalised rehabilitation care. Technology-based rehabilitation programs offer potential to replace or augment conventional face-to-face rehabilitation for providing continuum of care. We aimed to systematically develop a theory, evidence-driven, contextualised, and user-centred mobile health platform for people undergoing knee arthroplasty to facilitate monitoring progress during rehabilitation.

Exploring the genetic implications of demographic dynamics in Jammu and Kashmir using autosomal STRs.

The Union Territory of Jammu and Kashmir has always been a point of contention among India, Pakistan, and China for various reasons. This region has great significance historically due to its geography and ethnic diversity. However, a comprehensive genetic study providing the genetic landscape of Jammu and Kashmir was lacking until now.

Escape Rooms in Medical Education: Unlocking Realistic Simulated Clinical Scenarios Using Interprofessional Education.

The delivery of medical education is a complex process, considering the vast nature of the syllabus, and multiple competencies are needed to be attained by medical students. Escape rooms are an innovative approach to delivering medical education and provide an enriching learning experience for students. These rooms are designed to replicate clinical scenarios, and they provide a platform for students to apply their theoretical knowledge to clinical practice.

Facilitating Implementation of Shared Decision-Making in Medical Schools by Overcoming the Prevailing Challenges: A Brief Review.

The emergence of shared decision-making (SDM) in the field of medical education represents a significant shift in the way how health care is being taught to medical students and practiced by healthcare professionals. The purpose of the current review is to explore the merits of SDM to students and patients, identify the prevailing challenges in its successful implementation, and suggest appropriate solutions to overcome them. An extensive search of all materials related to the topic was performed on the PubMed search engine, and a total of 20 articles were selected.

Adoption of a Comprehensive Approach to Overcome the Challenges Involved in the Implementation of Social Accountability in Medical Education: A Brief Review.

In the field of delivery of medical education, social accountability envisages the responsibility of medical and healthcare institutions to meet the health-related needs of the communities in the catchment areas. The medical colleges that have integrated social accountability in their curriculum work with a goal to produce not only knowledgeable and skilled medical graduates but also those who are committed to the well-being of the entire community. The process of implementation of social accountability in medical education can have its own share of challenges.

Illuminating Medical Education Through Moral Case Deliberations: A Narrative Review.

In the field of medical education, moral case deliberations refer to a structured process, wherein health professionals together discuss and analyze moral issues or ethical dilemmas encountered in their clinical practice. The purpose of the current review is to explore the merits of moral case deliberations, identify the components, enumerate the strategies that can be used for implementation, and enlist the potential challenges and the remedial measures to overcome them. Moral case deliberations can be implemented in medical education in several ways that can be seamlessly integrated into the existing medical curriculum without stretching the overall duration of the training period.

Exploring the Scope of Theater of the Oppressed in Medical Education.

Theater of the oppressed has been regarded as a dynamic tool to bring about social change and empowerment of the audience. This theatrical exposure to medical students plays a significant role in the delivery of comprehensive training to medical students, which is not only restricted to clinical knowledge but extends to cultural and interpersonal skills to ensure the delivery of comprehensive patient care. In conclusion, the theater of the oppressed has the potential to prepare empathetic and compassionate medical practitioners.

Use of Technology to Promote Road Safety: Public Health Perspective.

Road safety has been acknowledged as a public health concern of global significance owing to its direct association with human lives and their well-being. Road safety is a much broader concept than measures that are aimed to just prevent accidents, but it extends to improving the quality of life of members of the community, safeguarding environmental health, and improving the economy of the nation. With the passage of time, several technologies in road safety have surfaced, and their collective employment can aid in the establishment of a smart, safe, and efficient transportation system in nations.

Exploring the Role of Technology in the Implementation of Social Accountability in Medical Education: A Brief Review.

Social accountability has been acknowledged as an important facet of medical education delivery as it envisages that healthcare professionals have the responsibility to be accountable for health-related community needs. The purpose of the current review is to identify the factors that determine the success of social accountability in medical education and explore different ways in which technology can aid in the implementation of social accountability initiatives in medical institutions. The successful implementation of socially accountable medical education depends on a broad gamut of factors, which can be associated with different stakeholders, including the role of technology in facilitating the implementation of the same.

The maternal genetic history of tribal populations of Chhattisgarh, India.

The central region of India boasts a rich tribal heritage and the highest number of tribal populations in the country. Analysing the genetic history of this population can offer valuable insights into various demographic processes that shaped the gene pool of present-day settlers of this region. In this study, we utilize a recently validated Next-generation sequencing (NGS) technique to sequence 24 tribal mitogenomes from the Chhattisgarh population for genetic ancestry and forensic analysis.

A Comprehensive Review on the Role of MRI in the Assessment of Supratentorial Neoplasms: Comparative Insights Into Adult and Pediatric Cases.

Magnetic resonance imaging (MRI) is a critical diagnostic tool in assessing supratentorial neoplasms, offering unparalleled detail and specificity in brain imaging. Supratentorial neoplasms in the cerebral hemispheres, basal ganglia, thalamus, and other structures above the tentorium cerebelli present significant diagnostic and therapeutic challenges. These challenges vary notably between adult and pediatric populations due to differences in tumor types, biological behavior, and patient management strategies.

A novel sensor-based digital instrument for assessment of quality of fibre extracted from banana pseudostem.

Banana () farming generates huge quantities of biomass, all of which goes to waste due to the non-availability of suitable technology for its commercial application. The potential solution to this issue could be the conversion of pseudo-stems into valuable assets by converting them into fibres for various textile and non-textile applications. The specific characteristics of banana pseudo-stem fibre i.

A Case of Postaxial Polydactyly Managed Under Local Anesthesia.

Polydactyly is a common occurrence, observed as the presence of extra digit/s in the hands and feet. It can be categorized into preaxial, postaxial, and mesoaxial forms based on the location of the additional digit. In most instances only a single extra digit is present, research reports with more than one extra digit have been published.

Conversion of anti-tissue factor antibody sequences to chimeric antigen receptor and bi-specific T-cell engager format.

Background: The efficacy of antibody-targeted therapy of solid cancers is limited by the lack of consistent tumour-associated antigen expression. However, tumour-associated antigens shared with non-malignant cells may still be targeted using conditionally activated-antibodies, or by chimeric antigen receptor (CAR) T cells or CAR NK cells activated either by the tumour microenvironment or following 'unlocking' via multiple antigen-recognition. In this study, we have focused on tissue factor (TF; CD142), a type I membrane protein present on a range of solid tumours as a basis for future development of conditionally-activated BiTE or CAR T cells.