Aseptic, semi-sealed cranial chamber implants for chronic multi-channel neurochemical and electrophysiological neural recording in nonhuman primates.

We developed an implantable neural interface for monitoring both chemical and electrical forms of brain activity in monkeys that maintains aseptic properties for year-long periods while leveraging the modular functions (e.g., sensor moveability) provided by a chamber system.

Micro-invasive probes for monitoring electrical and chemical neural activity in nonhuman primates.

We leveraged carbon fiber materials for creating sensors that provide dual neurochemical and electrical neural activity recording at micro-invasive (10 μm) spatial footprints proximal to recording sites, and enabling these measurements from deep brain targets of primates with conventional cranial chambers. These shaft-assisted micro-invasive probes (s-μIPs) are approximately 10 μm in diameter along the distal length (1 - 15 mm) immediately surrounding the targeted recording site. This micro-invasive portion ensures that the recording site is isolated from tissue damage induced by the wider shaft portion of the device.

Effects of SGLT2 Inhibitors on Cardiac Mechanics in Hispanic and Black Diabetic Patients.

Clinical trials demonstrating improved cardiovascular outcomes with SGLT2 inhibitors have often had limited representation from Black and Hispanic populations. While the mechanisms of action are not well known, ethnicity- or gender-based receptor physiology may render SGLT2 inhibitors a better agent in certain populations over others. A medical records query yielded diabetic patients initiated on SGLT2 inhibitors between 2013 and 2020.

Impact of right ventricular failure on the outcomes of acute inferior wall myocardial infarction.

Right ventricular failure (RVF) complicates 30-50% of cases with inferior wall myocardial infarctions (IWMI). Large-scale studies exploring the recent trends in morbidity and mortality of IWMI with RVF in the context of improved reperfusion strategies are currently lacking. The International Classification of Diseases, Tenth Revision, Clinical Modification codes were used to query the National Inpatient Sample of 2018-2019 to yield IWMI admissions and stratified based on presence of RVF.

Cardiac Structural and Functional Remodeling After Transcatheter Mitral Valve in Valve Implantation: Early Changes and Prognostic Significance.

Background: Transcatheter mitral valve-in-valve (MViV) replacement has emerged as an alternative to redo mitral valve (MV) surgery for the management of failed bioprosthetic MVs. The degree of cardiac remodeling assessed by echocardiography has been shown to have prognostic implications in degenerative mitral regurgitation patients undergoing MV surgery. The impact of transcatheter MViV in patients with degenerative bioprosthetic MV failure on cardiac remodeling and its associated prognosis remains undescribed.

Evaluating the Effect of Voice Quality Covariance on Auditory-Perceptual Evaluation Using a Novel Two-Dimensional Magnitude Estimation Task.

Purpose: Most people with dysphonia present with voices that vary along more than one voice quality (VQ) dimension. This study sought to examine the effect of covariance between breathy and rough VQ in natural voices.

Method: A two-dimensional matrix of 16 /a/ vowels was selected such that two VQ dimensions (breathiness and roughness) were sampled on a 4-point severity scale (none, mild, moderate, and severe).

Effects of Vibratory Source on Auditory-Perceptual and Bio-Inspired Computational Measures of Pediatric Voice Quality.

Objective: The vibratory source for voicing in children with dysphonia is classified into three categories including a glottal vibratory source (GVS) observed in those with vocal lesions or hyperfunction; supraglottal vibratory sources (SGVS) observed secondary to laryngeal airway injuries, malformations, or reconstruction surgeries; and a combination of both glottal and supraglottal vibratory sources called mixed vibratory source (MVS). This study evaluated the effects of vibratory source on three primary dimensions of voice quality (breathiness, roughness, and strain) in children with GVS, SGVS, and MVS using single-variable matching tasks and computational measures obtained from bio-inspired auditory models.

Methods: A total of 44 dysphonic voice samples from children aged 4-11 years were selected.

Evaluation and Management of Cardiac Sarcoidosis with Advanced Imaging.

A high clinical suspicion in the setting of appropriate history, physical exam, laboratory, and imaging parameters is often required to set the groundwork for diagnosis and management. Echocardiography may show septal thinning, evidence of systolic and diastolic dysfunction, along with impaired global longitudinal strain. Cardiac MRI reveals late gadolinium enhancement along with evidence of myocardial edema and inflammation on T2 weighted imaging and parametric mapping.

The impact of electrolytic pH on photoelectrochemical water oxidation.

Harnessing solar energy for clean and sustainable fuel production by photoelectrochemical water oxidation over different timescales has been extensively investigated. However, the light-driven photoelectrochemical water oxidation reaction for artificial photosynthesis suffers from poor photon-to-current efficiency. Herein, we demonstrate an experimental analysis of electrolytic pH on photoelectrochemical syngas production by varying the pH of the KOH and NaOH electrolytes using the N-ZnO photoelectrode and analyzing all variables.

Accelerating policy response to curb non-communicable diseases: an imperative to mitigate the dual public health crises of non-communicable diseases and COVID-19 in India.

Unlabelled: Non-communicable Diseases (NCDs) are a threat to public health and sustainable development. NCDs were equated to being a 'pandemic' before COVID-19 originated. Globally, NCDs caused approximately 74% of deaths (2019).

Impact of COVID-19 on Patients Hospitalized With Deep Vein Thrombosis and/or Pulmonary Embolism: A Nationwide Analysis.

The Coronavirus disease 2019 (COVID-19) infection predisposes patients to develop deep vein thrombosis (DVT) and pulmonary embolism (PE). In this study, we compared the in-hospital outcomes of patients with DVT and/or PE with concurrent COVID-19 infection vs those with concurrent flu infection. The National Inpatient Sample from 2019 to 2020 was analyzed to identify all adult admissions diagnosed with DVT and PE.

Impact of COVID-19 on Outcomes of Patients Hospitalized With STEMI: A Nationwide Propensity-matched Analysis.

Patients with ST-segment elevation myocardial infarction (STEMI) and concurrent coronavirus disease 2019 (COVID-19) have been reported to have poor outcomes. However, previous studies are small and limited. The National Inpatient Sample database for the year 2020 was queried to identify all adult hospitalizations with a primary diagnosis of STEMI, with and without concurrent COVID-19.

Development and Validation of a Single-Variable Comparison Stimulus for Matching Strained Voice Quality Using a Psychoacoustic Framework.

Purpose: Acoustic and perceptual quantification of vocal strain has been a vexing problem for years. To increase measurement rigor, a suitable single-variable matching stimulus for strain was developed and validated, based on the matching stimulus used previously for breathy and rough voice qualities.

Method: A set of 21 comparison stimuli for a single-variable matching task (SVMT) was synthesized based on a speech-shaped sawtooth waveform mixed with speech-shaped noise.

Interactions Between Breathy and Rough Voice Qualities and Their Contributions to Overall Dysphonia Severity.

Purpose: Dysphonic voices typically present multiple voice quality dimensions. This study investigated potential interactions between perceived breathiness and roughness and their contributions to overall dysphonia severity.

Method: Synthetic stimuli based on four talkers were created to systematically map out potential interactions.

Nationwide Analysis of the Outcomes and Mortality of Hospitalized COVID-19 Patients.

Introduction: The Coronavirus disease 2019 (COVID-19) pandemic has affected people worldwide with the United States (US) with the largest number of reported cases currently. Previous studies in hospitalized COVID-19 patients have been limited by sample size.

Methods: The National Inpatient Sample database which is the largest inpatient database in the US was queried in the year 2020 for the diagnosis of COVID-19 based on ICD-10-CM U07.

Predicting Perceived Vocal Roughness Using a Bio-Inspired Computational Model of Auditory Temporal Envelope Processing.

Purpose: Vocal roughness is often present in many voice disorders but the assessment of roughness mainly depends on the subjective auditory-perceptual evaluation and lacks acoustic correlates. This study aimed to apply the concept of roughness in general sound quality perception to vocal roughness assessment and to characterize the relationship between vocal roughness and temporal envelop fluctuation measures obtained from an auditory model.

Method: Ten /ɑ/ recordings with a wide range of roughness were selected from an existing database.

BiVO/FeO/ZnFeO; triple heterojunction for an enhanced PEC performance for hydrogen generation.

n/n/n triple heterojunction photoanodes made up of Zr:W-BiVO, FeO, and ZnFeO metal oxides are fabricated through a simplistic spray pyrolysis method. Use of Zr and W as dopants in BiVO plays an important role as Zr increases the carrier density and W reduces the charge recombination. Further, FeO and ZnFeO serve as a protective layer for Zr:W-BiVO, which augmented the photoelectrochemical performance and achieved a 1.

Potential inhibitors of SARS-CoV-2 (COVID 19) proteases PL and M/ 3CL: molecular docking and simulation studies of three pertinent medicinal plant natural components.

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - coronavirus disease 2019 (COVID-19) has raised a severe global public health issue and creates a pandemic situation. The present work aims to study the molecular -docking and dynamic of three pertinent medicinal plants , and phyto-compounds against SARS-COV-2 papain-like protease (PL) and main protease (M)/3-chymotrypsin-like protease (3CL). The interaction of protein targets and ligands was performed through AutoDock-Vina visualized using PyMOL and BIOVIA-Discovery Studio 2020.

Effects of Task Demands on Neural Correlates of Acoustic and Semantic Processing in Challenging Listening Conditions.

Purpose Listeners shift their listening strategies between lower level acoustic information and higher level semantic information to prioritize maximum speech intelligibility in challenging listening conditions. Although increasing task demands via acoustic degradation modulates lexical-semantic processing, the neural mechanisms underlying different listening strategies are unclear. The current study examined the extent to which encoding of lower level acoustic cues is modulated by task demand and associations with lexical-semantic processes.

Effect of morphology and impact of the electrode/electrolyte interface on the PEC response of FeO based systems - comparison of two preparation techniques.

The present study is a comparative account of FeO based photoelectrodes prepared by two different techniques, namely spray pyrolysis and electrochemical deposition, followed by photoelectrochemical analysis at pH 13 (highly alkaline) and pH 8 (near neutral) in 0.1 M NaOH solution for solar hydrogen generation. The study also investigates the influence of morphology at the semiconductor electrode/electrolyte interface along with quantitative determination of the morphological parameters of the rough electrode surface affecting the photoelectrochemical response using power spectral density analysis.

In Hospital Outcomes of Patients With Right Bundle Branch Block and Anterior Wall ST-Segment Elevation Myocardial Infarction (From a Nationwide Study Using the National Inpatient Sample).

Previous studies have reported worse outcomes for patients with right bundle branch block (RBBB) complicating acute ST-segment elevation myocardial infarction (STEMI). There is a paucity of data examining outcomes with RBBB and STEMI in contemporary large-scale studies. This study aims to explore the outcomes of patients with anterior wall STEMI (AW-STEMI) and RBBB.

Clinical Decision Support Tool and Rapid Point-of-Care Platform for Determining Disease Severity in Patients with COVID-19.

SARS-CoV-2 is the virus that causes coronavirus disease (COVID-19) which has reached pandemic levels resulting in significant morbidity and mortality affecting every inhabited continent. The large number of patients requiring intensive care threatens to overwhelm healthcare systems globally. Likewise, there is a compelling need for a COVID-19 disease severity test to prioritize care and resources for patients at elevated risk of mortality.

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19.

SARS-CoV-2 is the virus that causes coronavirus disease (COVID-19) which has reached pandemic levels resulting in significant morbidity and mortality affecting every inhabited continent. The large number of patients requiring intensive care threatens to overwhelm healthcare systems globally. Likewise, there is a compelling need for a COVID-19 disease severity test to prioritize care and resources for patients at elevated risk of mortality.