Publications by authors named "Shrinkhala Khanna"
Article Synopsis
- The study developed the Clonal Hematopoiesis Risk Score (CHRS) to assess the risk of clonal hematopoiesis (CH) in healthy individuals, but recognized that most CH cases are diagnosed when symptoms appear.
- Researchers examined clinical data from 94 CH patients, distinguishing between those with only DNMT3A/TET2/ASXL1 mutations ('sole DTA') and those with additional mutations ('non-sole DTA').
- Results revealed that TET2 was the most common mutation, sole DTA patients rarely progressed to myeloid neoplasm (MN), while non-sole DTA patients had a significant progression rate, especially if they had a RUNX1 mutation, indicating higher risk
BACKGROUND Heparin-induced thrombocytopenia (HIT) is a serious adverse effect of heparin, which can lead to a prothrombotic state. Prompt cessation of heparin and initiation of non-heparin anticoagulation is the standard of care for HIT. Nevertheless, the treatment can pose challenges, particularly in refractory HIT, in patients with contraindications to anticoagulation, or those requiring urgent surgery.
View Article and Find Full Text PDFExtramedullary myeloma, defined by presence of plasma cells outside the bone marrow, is a rare entity accounting for about 3-9% of all cases. It usually is aggressive with a median survival of <6 months. It is also associated with adverse prognostic factors including 17p deletions and high-risk gene profiles.
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