Effect of bioactive compounds of on proteins of Wnt/β catenin pathway in pulmonary hypertension by in silico approach.

Modulation of the Wnt/β-catenin signaling pathway may aid in discovering new medications for the effective management of pulmonary artery hypertension (PAH). Given the therapeutic potential of Mucuna pruriens in several diseases, the present study aimed to analyze interactions of different bioactive compounds of Mucuna pruriens plant seeds with Wnt/β-catenin pathway targeting its various components like Wnt 3a, Frizzled 1, LRP 5/6, β-catenin, Disheveled, cyclin D1 by in silico analysis. The proposed work is based on computational analysis including ADME/T properties, by a Swiss ADME server.

Comparison of Biomarkers of Oxidative Stress, Inflammation, and Endothelial Function Among Vegetarians and Non-vegetarians of Vijayapura, India: A Pilot Study.

Background: The known impact of diet on the pathophysiology of various chronic diseases and the current dietary transition in the country make it essential to assess the influence of dietary patterns specific to this region on inflammation, oxidative stress, and endothelial functions.

Objective: This study compared oxidative stress, inflammation, and endothelial functions among vegetarians and non-vegetarians in Vijayapura, Karnataka, India.

Methods: The present cross-sectional comparative study involved apparently healthy vegetarians (n=35) and non-vegetarians (n=35) aged 20-40.

Effect of on brain NMDA receptor and tau protein gene expression in cerebral ischemic rats.

Present study aimed to assess effect of pre-treatment with seed extract and its bioactive molecule(s) on NMDAR and Tau protein gene expression in cerebral ischemic rodent model. Methanol extract of seeds was characterized by HPLC, and β-sitosterol was isolated by flash chromatography. studies to observe the effect of pre-treatment (28 days) with methanol extract of seed and β-sitosterol on the unilateral cerebral ischemic rat model.

Low oxygen microenvironment and cardiovascular remodeling: Role of dual L/N.type Ca channel blocker.

Objective: Patients exposed to chronic sustained hypoxia frequently develop cardiovascular disease risk factors to ultimately succumb to adverse cardiovascular events. In this context, the present study intends to assess the role of cilnidipine (Cil), a unique calcium channel blocker that blocks both L-type and N-type calcium channels, on cardiovascular pathophysiology in face of chronic sustained hypoxia exposure.

Materials And Methods: The study involved Wistar strain albino rats.

Hypoxia and its preconditioning on cardiac and vascular remodelling in experimental animals.

Since oxygen (O) is indispensable for mammalian life, every cell in the body is endowed with mechanisms to detect and to respond to changes in the O levels in the microenvironment. The heart and the brain are the two most vital, life-supporting organs requiring a continuous supply of O to sustain their high metabolic rate. On being challenged with hypoxia, maintenance of O supply to these organs even at the cost of others becomes a priority.

Effect of L-Ascorbic Acid on Nickel-Induced Alteration of Cardiovascular Pathophysiology in Wistar Rats.

Nickel, a widely used heavy metal is suspected as a cardiotoxic element. The aim of the present study was to assess the possible protective role of l-ascorbic acid on nickel-induced alterations of cardiovascular pathophysiology in male albino rats. Twenty-four albino rats (b.

Subchronic hypoxia pretreatment on brain pathophysiology in unilateral common carotid artery occluded albino rats.

Objective: This study was aimed to assess the effect of unilateral common carotid artery occlusion on brain pathophysiology in rats pretreated with subchronic hypoxia.

Materials And Methods: Rats (200 ± 20 g) were randomized into three groups: Group 1 served as sham, Group 2 were normoxic (21% O and 79% N), and Group 3 were hypoxia preconditioned (10% O and 90% N) for 21 days before left common carotid artery occlusion (LCCAO). The LCCAO was done for 75 min followed by reperfusion for 12 h.

Impaired Pulmonary Lung Functions in Workers Exposed to Bagasse: Is Obesity an Added Risk?

Context: Effect of obesity and dust exposure on lung functions.

Aim: To assess the pulmonary functions in asymptomatic, dust-exposed sugarcane factory workers with obesity as an added risk.

Settings And Design: A cross-sectional study.

Primary concept of nickel toxicity - an overview.

Toxic metals, including excessive levels of essential metals tend to change biological structures and systems into either reversible or irreversible conformations, leading to the derangement of organ functions or ultimate death. Nickel, a known heavy metal is found at very low levels in the environment. Nickel is available in all soil types and meteorites and also erupts from volcanic emissions.

Protective effects of Ethanolic Extract of (amla) on Cardiovascular Pathophysiology of Rats, Fed with High Fat Diet.

Introduction: Dietary high fat alters lipid profile and possibly induce sympatho-vagal imbalance. is found to be potential antioxidant and possibly counteract hyperlipidemia induced lipid peroxidation.

Aim: To assess Ethanolic extract of (EEO) as lipid lowering and cardiovascular protective agent against high dietary fat supplemented to experimental rats.

A Prediction Formula for Double Product in Pregnancy.

Introduction: Maternal cardiovascular changes in pregnancy are numerous and increase in double product throughout pregnancy is the part of the same process. Double product is a cardinal surrogate of the myocardial oxygen demand and cardiac workload. It is the product of heart rate and systolic blood pressure and an important determinant of cardiovascular risk in hypertensive patients.

Different anthropometric adiposity measures and their association with cardiovascular disease risk factors in middle aged women.

A cross sectional study of 136 women age group40-55 years was conducted to study which anthropometric measure had the strongest association with cardiovascular disease risk factors in middle aged women. In accordance with their BMI measurement subjects were divided into three groups namely: Normal weight (Group1) BMI 18.5-24.

Alterations in minute ventilation, maximum voluntary ventilation and dyspneic index in different trimesters of pregnancy.

Respiratory function in pregnancy is of special importance since the life of fetus depends primarily upon its oxygen supply. Thus this study was designed to evaluate the Minute ventilation (MV), Maximum Voluntary Ventilation (MVV) & Dyspneic Index (DI) in different trimesters of pregnancy & compare the results with non- pregnant control group. A cross-sectional study was carried out in 200 healthy women in the age range of 19-35 years with 50 subjects each in 1st, 2nd, 3rd trimesters of pregnancy and non-pregnant control group.

Role of yoga in modifying anxiety level in women.

Anxiety leads to derangement in physical and mental health. Anxiety levels are more in full time housewives than working women. There is a need for simple, easy treatment for anxiety to alleviate the burden on health caused by anxiety.

Reduction in lung functions in type-2 diabetes in Indian population: correlation with glycemic status.

The purpose of this study was to evaluate pulmonary functions in patients with Type-2 diabetes mellitus and to determine their correlation with glycemic status of diabetes in Indian population. Forty Type-2 diabetic patients, aged 30-60 years, with diabetic duration of 1-20 years, were included in the study. FVC, FEV1, & FEV1% are recorded by Benedict's Roth spirometer.