Synthetic tactics of new class of 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives acting as antimicrobial agents.

Thermal selective reactions were studied on oxothieno[2,3-d]pyrimidine-6-carboxamide 3 with POCl3 and PCl5. At 25-50 °C, the C7-amide rearranges to nitrile furnished compound 4 in 85-90% yield, while at 80-110 °C furnished mixture of products 4 and 5 in 28-68% yields. The chloro displacement with amines in compound 5 yielded 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives 8(a-h) and 9(a-e).

Aminothiophenedicarboxamides and dicyanothiopheneacetamides as effective synthetic molluscicides against Indoplanorbis exustus snail.

New thiophenedicarboxamide 2a-c and dicyanothiopheneacetamide 3a-c derivatives were synthesized and their bioactivity against Indoplanorbis exustus snails was evaluated. The I. exustus snail is a serious host of parasite of genus Schistosoma which infects cattle.

Synthesis of quinolone substituted pyrazoles, isoxazoles and pyridines as a potential blue luminophors.

Series of quinolone C(3)-substituted pyrazolines, isoxazolines, pyridines and pyrimidines were synthesized in good yields by the cyclocondensation reactions of 1, 2-unsaturated ketones and hydrazines, hydroxylamine hydrochloride and dimedone respectively. The quinolone derivatives (3, 5 and 7) were synthesized and further studied for their photophysical properties. High absorption and quantum yield are found for N(1)-phenyl and C(3,4)-dimethoxy substituents on phenyl ring (3h).