Publications by authors named "Shreyas Madiwale"

Article Synopsis
  • The ERG transcription factor is linked to various cancers, particularly leukemia, but its specific mechanisms and interactions are not well understood.
  • Our research highlights the importance of proline at position 199 in the PNT domain of ERG, which is essential for its role in promoting leukemia by enabling self-renewal and inhibiting myeloid differentiation.
  • We found that proline 199 allows ERG to interact with the NCoR-HDAC3 co-repressor complex, and blocking HDAC3 slows down the growth of cancers driven by ERG, suggesting that targeting this interaction could be a new treatment strategy.
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Mixed-phenotype acute leukemia is a rare subtype of leukemia in which both myeloid and lymphoid markers are co-expressed on the same malignant cells. The pathogenesis is largely unknown, and the treatment is challenging. We previously reported the specific association of the recurrent t(8;12)(q13;p13) chromosomal translocation that creates the ETV6-NCOA2 fusion with T/myeloid leukemias.

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As treatment protocols for medulloblastoma (MB) are becoming subgroup-specific, means for reliably distinguishing between its subgroups are a timely need. Currently available methods include immunohistochemical stains, which are subjective and often inconclusive, and molecular techniques-e.g.

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One of the major pathological outcomes of DNA damage during aging or anticancer therapy is enhanced inflammation. However, the underlying signaling mechanism that drives this is not well understood. Here, we show that in response to DNA damage, ubiquitously expressed GPCR, CXCR4 is upregulated through the ATM kinase-HIF1α dependent DNA damage response (DDR) signaling, and enhances inflammatory response when activated by its ligand, chemokine CXCL12.

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