Publications by authors named "Shreyas M Gadre"
Cell Death Differ
July 2018
Article Synopsis
- Therapy resistance in advanced non-small cell lung cancer (NSCLC) is a significant issue, as cancer stem cells (CSCs) are often left behind after conventional treatment, contributing to relapse and metastasis.
- The study identifies the mitochondrial citrate transporter SLC25A1 as crucial for the energy production and survival of lung CSCs, where its inhibition leads to the disruption of their self-renewal capability.
- A new SLC25A1 inhibitor has shown potential to work synergistically with standard treatments like cisplatin or EGFR inhibitors, suggesting a promising strategy to improve therapy responses in drug-resistant lung CSCs.
