There is significant variability in the severity of post-stroke aphasia, and traditional prediction methods often overlook neurophysiological and genetic factors that could influence recovery.
The study aims to determine if a specific genetic variant (ValMet) in the BDNF gene affects aphasia severity and interacts with neuroplasticity indicators to enhance recovery predictions.
Results showed that individuals with the ValVal genetic variant had less severe aphasia and exhibited expected age-related effects, while ValMet carriers displayed weaker correlations with neuroplasticity indicators, indicating the genetic variant’s role in recovery outcomes.