Publications by authors named "Shreya V Udani"
Article Synopsis
- Outcomes of traumatic brain injury (TBI) are inconsistent among patients with similar injuries, posing challenges for prognosis and treatment innovation.
- Recent research has identified specific genetic variations, specifically single nucleotide polymorphisms (SNPs), that could help tailor therapies and improve clinical trial designs.
- The review primarily examines the Val66Met SNP in the BDNF gene, which affects neurological recovery and is influenced by multiple factors like ethnicity, age, gender, and the severity of injury, complicating the relationship between genetics and TBI outcomes.
Naturally evolved metabolite-responsive biosensors enable applications in metabolic engineering, ranging from screening large genetic libraries to dynamically regulating biosynthetic pathways. However, there are many metabolites for which a natural biosensor does not exist. To address this need, we developed a general method for converting metabolite-binding proteins into metabolite-responsive transcription factors-Biosensor Engineering by Random Domain Insertion (BERDI).
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