Publications by authors named "Shreya Sudhir"
Article Synopsis
- Polysialic acid (polySia) modifies cell-surface proteins and influences immune cell interactions, particularly during infections like Streptococcus pneumoniae (Spn).
- ST8SiaIV mice lacking polySia show reduced susceptibility to Spn, faster airway clearance, and improved macrophage function, despite having fewer leukocytes recruited to the lungs.
- The decrease in leukocyte migration and altered immune response may be linked to abnormal ERK1/2 signaling, indicating potential therapeutic strategies for enhancing immunity by targeting polySia function.
