Defective FGFR1 Signaling Disrupts Glucose Regulation: Evidence From Humans With Mutations.

Context: Activation of fibroblast growth factor receptor 1 (FGFR1) signaling improves the metabolic health of animals and humans, while inactivation leads to diabetes in mice. Direct human genetic evidence for the role of FGFR1 signaling in human metabolic health has not been fully established.

Objective: We hypothesized that individuals with naturally occurring variants ("experiments of nature") will display glucose dysregulation.

Estimation of age implementing pulp tooth volume ratio in maxillary canines of an Indian population by means of CBCT scans.

Background: Forensic odontology is a subfield of forensics that can assist in determining age, gender, and other demographic factors.

Objective: The focus of this research is to ascertain age by tooth volume ratio of permanent maxillary canines using a CBCT scan.

Methods: In this retrospective investigation, 1000 CBCT images were gathered and focused on only fully developed maxillary canines.