Publications by authors named "Shreya Ingle"
Outcomes for glioblastoma (GBM) remain poor despite standard-of-care treatments including surgical resection, radiation, and chemotherapy. Intratumoral heterogeneity contributes to treatment resistance and poor prognosis, thus demanding novel therapeutic approaches. Drug repositioning studies on antiretroviral therapy (ART) have shown promising potent antineoplastic effects in multiple cancers; however, its efficacy in GBM remains unclear.
View Article and Find Full Text PDFLaser interstitial thermal therapy (LITT) is a minimally invasive neurosurgical technique used to ablate intra-axial brain tumors. The impact of LITT on the tumor microenvironment is scarcely reported. Nonablative LITT-induced hyperthermia (33-43˚C) increases intra-tumoral mutational burden and neoantigen production, promoting immunogenic cell death.
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- Herpes Simplex Virus-1 (HSV-1) can mimic symptoms of Glioblastoma (GBM), complicating diagnosis, and there’s limited research on how these illnesses coexist.
- A review identified 20 cases where HSV-1 caused herpetic encephalitis (HSE) in GBM patients, revealing an overall survival rate of just 8 months, with a notable predictor being the timing of HSE diagnosis.
- The presence of HSE in GBM patients may lead to worse survival outcomes, but early diagnosis of HSE could enhance survival prospects due to immune response activation; hence, immediate antiviral treatment is crucial.
Objective: Increasing centralization of high-level neurosurgical practice at academic centers has increased the need for academic neurosurgeons. The lack of systematic metrics-based analyses among neurosurgery trainees and the recent pass/fail U.S.
View Article and Find Full Text PDFBackground: Untreated pediatric choledochal cyst (CC) is associated with complications including cholangitis, pancreatitis, and risk of malignancy. Therefore, CC is typically treated by surgical excision with biliary reconstruction. Both open and laparoscopic (lap) surgical approaches are regularly used, but outcomes have not been compared on a national level.
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- The study investigates outcomes of heart-lung transplantation (HLTx) among Asian recipients compared to non-Hispanic White recipients, highlighting the need for equitable access to this procedure in a diverse U.S. population.
- The analysis utilized data from patients aged 18 and older who underwent HLTx from 1987 to 2021, matching Asian patients with non-Hispanic Whites to identify trends in survival and health post-transplant.
- Findings indicated no significant differences in median survival or post-transplantation outcomes between the two groups, suggesting that positive outcomes in Asian patients could encourage more HLTx procedures in Asian countries where they are less common.
Background: The benefits of mechanical thrombectomy for emergent large vessel occlusion (ELVO) have been established. Combined mechanical/aspiration (Solumbra) and a direct aspiration as a first pass technique (ADAPT) are valid procedures requiring an intermediate catheter for clot suction. Recently, SOFIA (Soft torqueable catheter Optimized For Intracranial Access) was developed as a single lumen flexible catheter with coil and braid reinforcement, but its suitability for mechanical thrombectomy had not been evaluated.
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