Publications by authors named "Shreesha Rao"

Members of the myxovirus resistance (Mx) protein family play an essential role in antiviral immunity. They are Dynamin-like GTPases, induced by interferons. In the current study, we have characterized two predicted MX genes (MX1 and MX2) from lumpfish (Cyclopterus lumpus L.

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  • The JAK-STAT signaling pathway plays a key role in regulating gene transcription in response to cytokines and growth factors, and this study focused on characterizing STAT genes in lumpfish.
  • Various methods were used to analyze the evolutionary relationships and responses of the JAK-STAT pathway when exposed to bacteria and poly(I:C), a substance that mimics viral infections.
  • The results indicated that lumpfish possess several STAT genes, which are highly conserved, and showed significant upregulation of specific genes in response to bacterial and viral challenges, highlighting a foundation for future research and the potential for vaccination strategies against diseases affecting lumpfish.
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Lactococcosis, caused by Lactococcus garvieae, is an acute hemorrhagic septicemia in fish recorded in marine and freshwater aquaculture during the summer months. In 2020-2021, several sea cage Pompano farms recorded sudden fish mortality events. Based on the results of phenotypic and biochemical tests, L.

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Background: Both bacterial and viral diseases are a major threat to farmed fish. As the antiviral immune mechanisms in lumpfish ( L.) are poorly understood, lumpfish leukocytes were stimulated with poly(I:C), a synthetic analog of double stranded RNA, which mimic viral infections, and RNA sequencing was performed.

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  • The study focuses on pisciene nocardiosis, a disease in fish caused by Nocardia seriolae, which is problematic in South-East Asian aquaculture.
  • Researchers conducted experiments on live and killed cells of N. seriolae, observing that delipidation altered key characteristics and reduced immune resistance in fish.
  • Results showed that delipidated cells were less virulent, leading to lower mortality rates in fish and changes in immune response, demonstrating that the virulence of nocardial lipids is crucial to its pathogenicity regardless of the cell's living status.
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Lactococcus garvieae is the etiological agent of Lactococcosis, an evolving disease affecting many fish species and causing significant economic losses worldwide. Assessing pathogen relatedness and bacterial population structure is critical for determining the epidemiology of L. garvieae infections and in establishing effective pathogen management methods.

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For the first time, Longicollum pagrosomi Yamaguti, 1935, an acanthocephalan parasite, has been characterized with morphological, histopathological and molecular detail in farmed red snapper (Lutjanus erythropterus) in Taiwan. The diseased fish showed clinical signs of anorexia, emaciation and were gasping for air at the water's surface. Gross examination revealed extensive necrosis in the intestine and even penetration at the site of parasitic attachment, resulting in a large number of parasites being lodged in the peritoneal cavity, surrounded by black hyperplastic connective tissue.

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Vaccination is the most effective, safe, and environmentally friendly method to prevent the outbreak of Photobacterium damselae subsp. piscicida (Phdp), a dangerous pathogen in aquaculture worldwide. Here, recombinant proteins of catalase, superoxide dismutase, isocitrate dehydrogenase, fructose 1,6-bisphosphate aldolase (Fba), and a mixture of all four proteins were investigated for their immunoprotective effects against photobacteriosis in Asian sea bass (Lates calcarifer).

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Chinese softshell turtles (Pelodiscus sinensis) (CST) are susceptible to infections by bacteria belonging to the Bacillus cereus group (Bcg). Bcg includes several closely related species, two of which, B. cereus and B.

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The diseased cage-cultured cobia (Rachycentron canadum) displayed clinical signs, haemorrhagic eyes, dorsal darkness and gross pathological lesions, enlargement of spleen and liver. Haemorrhages were found in brain, heart and liver with cumulative mortality rates ranging from 20% to 50%. Extensive congestion in the heart, liver, spleen, kidney and brain was observed histopathologically.

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