Publications by authors named "Shree L Kandasamy"
Article Synopsis
- - The study investigated the role and mutations of the XBB omicron variant in COVID-19 cases among hospitalized patients in Tamil Nadu, India, particularly in the context of increased breakthrough infections despite vaccination efforts.
- - Researchers analyzed nasopharyngeal and oropharyngeal swabs from 98 patients using real-time PCR and Next Generation Sequencing, identifying 43 mutations in the S gene, including two new mutations, A27S and T747I, which had not been previously reported.
- - The findings suggested that factors such as age and underlying health conditions were more critical in susceptibility to infection than vaccination status, with XBB.3 being the main variant identified among vaccinated individuals experiencing breakthrough infections.
Attributes contributing to the current monkeypox virus (MPXV) outbreak remain unknown. It has been established that mutations in viral proteins may alter phenotype and pathogenicity. To assess if mutations in the MPXV DNA replication complex (RC) contribute to the outbreak, we conducted a temporal analysis of available MPXV sequences to identify mutations, generated a DNA replication complex (RC) using structures of related viral and eukaryotic proteins, and structure prediction method AlphaFold.
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