Neurocognitive profile in adolescents with early-onset schizophrenia: clinical correlates.

Background: Neurocognitive impairments have been documented in adolescents with early-onset schizophrenia (EOS; onset by age 18) and are important treatment targets. Information concerning the severity, pattern, and clinical correlates of these deficits in EOS remains limited.

Methods: Tests assessing motor skills, attention, memory, visuospatial abilities and executive functioning were administered to 54 clinically stabilized adolescents with EOS and 52 age- and sex-matched healthy controls.

Attention-deficit/hyperactivity disorder: a preliminary diffusion tensor imaging study.

Background: The purpose of this study was to explore whether there are white matter (WM) abnormalities in children with attention-deficit/hyperactivity disorder (ADHD) using diffusion tensor imaging. Based upon the literature, we predicted decreased fractional anisotropy (FA) findings in the frontal and cerebellar regions.

Methods: Eighteen patients with ADHD and 15 age- and gender-matched healthy volunteers received DTI assessments.