North Pontic crossroads: Mobility in Ukraine from the Bronze Age to the early modern period.

The North Pontic region, which encompasses present-day Ukraine, was a crossroads of migration, connecting the vast Eurasian Steppe with Central Europe. We generated shotgun-sequenced genomic data for 91 individuals dating from around 7000 BCE to 1800 CE to study migration and mobility history in the region, with a particular focus on historically attested migrating groups during the Iron Age and the medieval period. We infer a high degree of temporal heterogeneity in ancestry, with fluctuating genetic affinities to different present-day Eurasian groups.

Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome.

Abdominal obesity coupled with polygenic hereditary defects is considered the initial event in the development of metabolic syndrome (MS). The purpose of this study was to analyse the frequency with which polymorphic loci of adiponectin () and leptin () genes occur in patients with MS and the association between the symptoms of MS and these polymorphisms. DNA was isolated from the whole blood of 207 patients with MS and 100 healthy individuals (control group) using the phenol-chloroform method.

Polymorphism in Adiponectin and Adiponectin Receptor Genes in Diabetes Mellitus Pathogenesis.

The role played by hereditary factors in the development of diabetes mellitus type 2 (DM2) has not yet been fully established. Therefore, the purpose of our study was to investigate the prevalence of adiponectin and polymorphism in its gene receptors in connection with the primary symptoms of DM2 pathogenesis. Genomic DNA was isolated from the whole blood of 94 patients with an established diagnosis of DM2 using the phenol-chloroform method.

Dysregulation of VEGF-dependent angiogenesis in cavernous lung tuberculosis.

Introduction: Tuberculosis (TB) remains one of the most dangerous infections with the high mortality in the whole world. The leading problems in the modern course of TB are both long-term therapy and appearance of multiplying and wide resistant forms, as well as the rise of comorbid pathology (e.g.

Shifts in the Genetic Landscape of the Western Eurasian Steppe Associated with the Beginning and End of the Scythian Dominance.

The Early Iron Age nomadic Scythians have been described as a confederation of tribes of different origins, based on ancient DNA evidence [1-3]. It is still unclear how much of the Scythian dominance in the Eurasian Steppe was due to movements of people and how much reflected cultural diffusion and elite dominance. We present new whole-genome sequences of 31 ancient Western and Eastern Steppe individuals, including Scythians as well as samples pre- and postdating them, allowing us to set the Scythians in a temporal context (in the Western, i.

[Effect of xenobiotics on alveolar macrophages].

Under the action of hexachlorcyclogexan in concentration not exceeding the pesticides residues in food staffs the prominent adaptive mechanisms stress of gematoalveolar barier is seen. However, the adaptation has the extensive character and is caused by increase of alveolar monocytes in broncho-alveolar lavage. The phagocytosis functional reservers exceed the control values, but phagocytes activity and phagocytory index remain decreased and reach norms just after the xenobiotic abolition.

[Morphofunctional characteristics of alveolar macrophages under the effect of a toxic factor].

The work was conducted on Wistar rats who had received orally the xenobiotic hexachlorocyclohexane (HClCH) in different doses. The sizes of the alveolar macrophages and type II pneumocytes as well as the parameters of macrophage phagocytosis were studies. Administration of HClCH in subtoxic doses not exceeding the pesticide residues in the food in the first two months stimulated synthesis of the surfactant and its phagocytosis by the alveolar macrophages; further administration of the primer led to exhaustion of the cell function.

[Effectiveness of the use of proteolytic enzymes in extracapsular cataract extraction].

Experimental and clinical study of lekozim and collalysine proteolytic enzymes efficacies in extracapsular cataract extraction was carried out. Local application of these agents in irrigation aspiration of the cortical mass from the capsule sac equator not only simplified the technique of the most intricate stage of surgery, but also proved to be a sufficiently effective means of secondary cataract prevention. A follow-up of up to 3 years has shown secondary cataract development in 5 percent of patients after extracapsular cataract extraction administered lekozim, in 10 percent of those administered collalysine, and in 17.

[The status of the iridocorneal angle after the implantation of anterior chamber intraocular lenses with flexible supporting elements].

The study was undertaken to examine the status of the iridocorneal angle (ICA) 1 to 4 years after implantation of anterior chamber intraocular lens with flexible supporting devices designed by M. L. Dvali.

[Secondary implantation of the anterior-chamber intraocular lenses with flexible supportive elements for correction of aphakia].

The authors have designed an anterior-chamber intraocular lens (IOL) with flexible supporting elements and examined the possibility of its application for secondary correction of aphakia. Secondary implantations of such IOLs have been performed in 25 eyes. The implantation has proved to be low-traumatic and effective: the vision acuity has been unchanged or improved in 92% of cases, the loss of endothelial cells has made up 8.