Publications by authors named "Show-Ling Yang"
The causal relationship between body mass index (BMI) and type 2 diabetes (T2D) and breast cancer prognosis is still ambiguous. The aim of this study was to investigate the prognostic effect of BMI and T2D on breast cancer disease-free survival (DFS) among Asian individuals. In this two-sample Mendelian randomization (MR) study, the instrumental variables (IVs) were identified using a genome-wide association study (GWAS) among 24,000 participants in the Taiwan Biobank.
View Article and Find Full Text PDFThe Taiwanese people are composed of diverse indigenous populations and the Taiwanese Han. About 95% of the Taiwanese identify themselves as Taiwanese Han, but this may not be a homogeneous population because they migrated to the island from various regions of continental East Asia over a period of 400 years. Little is known about the underlying patterns of genetic ancestry, population admixture, and evolutionary adaptation in the Taiwanese Han people.
View Article and Find Full Text PDFArticle Synopsis
- The Taiwan Biobank (TWB) is developing a comprehensive research database that includes genomic, lifestyle, and health data from 300,000 residents of Taiwan.
- An analysis of 10,801 Taiwanese Han Chinese participants revealed three distinct genetic clusters based on ancestry: 5% northern, 79.9% southern, and 14.5% a unique T group with independent evolutionary traits.
- This study also found different genetic risk factors for type II diabetes among the various Han Chinese ancestry groups and made the genetic data publicly available to promote further research.