The Role and Mechanism of Vascular Aging in Geriatric Vascular Diseases.

Vascular aging is the pathological basis for the aging of various organ systems in the human body and is a common pathogenesis leading to the development of atherosclerosis, Alzheimer's disease, and other conditions among older adults. Aging is characterized by accelerated pulse wave velocity, thickening of the carotid artery intima-media, and decreased vascular dilation function. Signaling pathways such as mTOR, AMPK, NF-κB, Klotho, SIRT, and other key proteins are likely involved in these processes.

A bibliometric analysis of traditional Chinese non-pharmacological therapies in the treatment of knee osteoarthritis from 2012 to 2022.

Objective: The benefits of traditional Chinese non-pharmacological therapies in the treatment of Knee osteoarthritis (KOA) are receiving increasing attention. Therefore, this study aims to systematically analyze the global research on the treatment of KOA by Chinese traditional non-pharmacological therapies using bibliometric analysis and present the results with a knowledge map form.

Methods: Literature related to traditional Chinese non-pharmacological therapies used in the treatment of KOA from 2012 to 2022 was searched from the Web of Science core database and PubMed database.

Effect and Mechanism of Traditional Chinese Medicine Exercise Therapy on Stroke Recovery.

Stroke is currently the second largest contributor to disability-adjusted life years (DALYs) in developing countries, and it is the third largest contributor to DALYs in developed countries. It requires a large number of resources from the health care system every year, which places a great burden on society, families, and individuals. The treatment of traditional Chinese medicine exercise therapy (TCMET) during stroke recovery has become a hot topic of current research due to its few adverse events and high efficiency.

A bibliometric analysis of research trends of artificial intelligence in the treatment of autistic spectrum disorders.

Objective: Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder that has become the leading cause of disability in children. Artificial intelligence (AI) is a potential solution to this issue. This study objectively analyzes the global research situation of AI in the treatment of ASD from 1995 to 2022, aiming to explore the global research status and frontier trends in this field.

[The quality standard study on Hugan qingzhi tablets].

Objective: To develop a method of quality control for Hugan qingzhi tablets.

Methods: Fructus Crataegi, Rhizoma Alismatis and Radix Notoginseng were identified by TLC. HPLC was used for the determination of ursolic acid in Hugan qingzhi tablets.

Preparation of nanoparticles of Magnolia bark extract by rapid expansion from supercritical solution into aqueous solutions.

A rapid expansion from supercritical solution into aqueous solution (RESSAS) technology was presented for the micronization of Chinese medicinal material. Magnolia bark extract (MBE) obtained by supercritical carbon dioxide (scCO₂) extraction technology was chosen as the experimental material. RESSAS process produced 303.

[Determination of rat serum emodin level by microemulsion liquid chromatography with direct sample loading].

Objective: To establish a microemulsion liquid chromatography system with direct sample loading for determining the serum level of emodin in rats.

Methods: The separation was performed on C₁₈ column (Hypersil BDS, 5 µm,150 mm×4.6 mm) with the microemulsion mobile phase consisting of 3.

Micronization of magnolia bark extract with enhanced dissolution behavior by rapid expansion of supercritical solution.

A rapid expansion of supercritical solution (RESS) technology was presented for the micronization of Chinese medicinal material. Magnolia bark extract (MBE) obtained by supercritical carbon dioxide (scCO(2)) extraction technology was chosen as the experimental material. RESS process produced 4.

[Micronization of magnolia bark extract by RESS as well as dissolution and pharmacokinetics evaluation].

The purpose of this study is to explore the feasibility and superiority of using rapid expansion of supercritical solution (RESS) technology in the field of traditional Chinese medicine. The extract of magnolia bark (EMB) was obtained by supercritical carbon dioxide (SCF-CO2) extraction technology. Microparticles of EMB were manufactured by RESS technology.

[Preparation of nanopaticles of SCF-CO2 extraction of Magnolia officinalis].

Objective: To prepare nano-particles of SCF-CO2 extraction of Magnolia officinalis with rapid expansion of supercritical solution (RESS) and optimize the preparation procedure with orthogonal experiment.

Method: The preparation procedures were optimized by orthogonal test L9(3(4)) with the mean particle size and the amounts of total-phenol as indexes. Factors of the extraction pressure and temperature, diameter of nozzle, pre-expansion temperature were evaluated for their effects on preparation process.

[Preparation of tanshinone transfersome and its deformability].

Objective: To prepare tanshinone transfersome (TTs) and evaluate its deformability.

Methods: The transfersomes were prepared by film dispersion method followed by sonication, and their physical properties, morphology, content, entrapment efficiency, particle size, polydispersity, and Zeta potential were investigated. The stability and deformability of TTs were studied.

[Observations on the efficacy of Botai ointment in treating dermatosis common among armed forces receiving at-sea training].

Objective: To observe the efficacy of Botai ointment in the treatment of common dermatosis.

Methods: Botai ointment was the only drug applied for the treatment. The ointment was smeared on the affected area twice daily for 4 weeks.

Determination of L-sesamin and L-asarinin in Zanthoxylum(Roxb.) DC. by high performance liquid chromatography.

Objective: To establish a method for determining the content of L-sesamin and L-asarinin indifferent parts of Zanthoxylum(Roxb.)DC.

Method: High-performance liquid chromatography (HPLC) was utilized for this purpose with the column of HYPERSIL BDS C18 and the mobile phase containing acetonitrile and water (50:50), the detection wavelength being 287 nm.