Publications by authors named "Shourui Hu"
Article Synopsis
- Polycystic ovary syndrome (PCOS) is linked to metabolic issues, but the exact connections and treatment methods are still unclear, prompting the need for a detailed investigation on metabolic causes and drug targets.
- Using advanced statistical methods and a large dataset of over 10,000 PCOS cases and more than 100,000 controls, the study found that body mass index (BMI), triglycerides, LDL cholesterol, and type 2 diabetes increase the risk of developing PCOS, while high-density lipoprotein cholesterol (HDL) appears to reduce that risk.
- The research also identified several potential drug therapies, including incretin-based medications and PCSK9 inhibitors, which could be effective in treating
Background: Excessive energy intake in modern society has led to an epidemic surge in metabolic diseases, such as obesity and type 2 diabetes, posing profound threats to women's reproductive health. However, the precise impact and underlying pathogenesis of energy excess on female reproduction remain unclear.
Methods: We established an obese and hyperglycemic female mouse model induced by a high-fat and high-sucrose (HFHS) diet, then reproductive phenotypes of these mice were evaluated by examing sexual hormones, estrous cycles, and ovarian morphologies.
Background: Excessive hepatic glucose production is a hallmark that contributes to hyperglycemia in type 2 diabetes (T2D). The regulatory network governing this process remains incompletely understood. Here, we demonstrate that TOX3, a high-mobility group family member, acts as a major transcriptional driver for hepatic glucose production.
View Article and Find Full Text PDFImpaired insulin secretion is a hallmark in type 2 diabetes mellitus (T2DM). THADA has been identified as a candidate gene for T2DM, but its role in glucose homeostasis remains elusive. Here we report that THADA is strongly activated in human and mouse islets of T2DM.
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