Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis.

Corosolic acid (CRA), a pentacyclic triterpene isolated from medicinal herbs, has been reported to exhibit anticancer properties in several cancers. However, the anticancer activity of CRA in osteosarcoma cells is still unclear. In the present study, the inhibitory effect of CRA in osteosarcoma MG-63 cells was investigated, and the results revealed that CRA significantly inhibited the viability of MG-63 cells in a dose- and time-dependent manner.

Expression of metastasis-associated protein 3 in human brain glioma related to tumor prognosis.

Glioma represents a disparate group of tumors characterized by high invasion ability, and therefore it is of clinical significance to identify molecular markers and therapeutic targets for better clinical management. Previously, metastasis-associated protein family (MTA) is considered to promote tumor cell invasion and metastasis of human malignancies. Recently, the newly identified MTA3 has been shown to play conflicting roles in human malignancies, while the expression pattern and potential clinical significance of MTA3 in human glioma have not been addressed yet.

In vitro and in vivo study of a sodium chloride impregnated microarc oxidation-treated titanium implant surface.

Microarc oxidation (MAO) has been well-documented as an advantageous surface coating technique to improve implant osseointegration. Nevertheless, its strong susceptibility to bacteria critically impedes the development of MAO in clinical trials. Aimed at the efficient inhibition of bacterial invasion of MAO treated titanium (MAO-Ti) implants, a composite coating created by applying sodium chloride (NaCl) on a MAO-Ti implant surface layer was designed herein with the capacity to resist a broad spectrum of bacteria.