Publications by authors named "Shoumit Mukhopadaya"
Article Synopsis
- Peripheral nerve injuries lead to significant disability and chronic pain, affecting quality of life, with current treatments mainly using autografts.
- Electrospun nanofiber conduits show promise in bridging nerve gaps, but the impact of surface features on nerve regeneration is not well understood.
- This study revealed that aligned fibers promote better nerve regeneration through specific cellular responses and gene expressions, indicating that topographical cues could enhance strategies for effective nerve repair.
Bridging of long peripheral nerve gaps remains a significant clinical challenge. Electrospun nanofibers have been used to direct and enhance neurite extension in vitro and in vivo. While it is well established that oriented fibers influence neurite outgrowth and Schwann cell migration, the mechanisms by which they influence these cells are still unclear.
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