Subclones of bone marrow CD34 cells in acute myeloid leukemia at diagnosis confer responses of patients to induction chemotherapy.

Background: Acute myeloid leukemia (AML) is a hematopoietic malignancy with a prognosis that varies with genetic heterogeneity of hematopoietic stem/progenitor cells (HSPCs). Induction chemotherapy with cytarabine and anthracycline has been the standard care for newly diagnosed AML, but about 30% of patients have no response to this regimen. The resistance mechanisms require deeper understanding.

An approach to high-throughput growth of submillimeter transition metal dichalcogenide single crystals.

High-throughput growth of large size transition metal dichalcogenide (TMD) single crystals is an important challenge for their applications in the next generation electronic and optoelectronic integration devices. Here we report the high-throughput growth of submillimeter monolayer TMD single crystals by two-stage space confined chemical vapor deposition, where the nucleation density of TMD crystals is significantly decreased for the growth of large size monolayer crystals by the space confinement effect. Moreover, high-throughput growth of submillimeter TMD crystals is also achieved by stacking the substrates along the perpendicular direction to the flow of the reaction gases.

Metal Induced Growth of Transition Metal Dichalcogenides at Controlled Locations.

Metal induced nucleation is adopted to achieve the growth of transition metal dichalcogenides at controlled locations. Ordered arrays of MoS and WS have successfully been fabricated on SiO substrates by using the patterned Pt/Ti dots as the nucleation sites. Uniform MoS monolayers with the adjustable size up to 50 μm are grown surrounding these metal patterns and the mobility of such layer is about 0.

iNuc-PseKNC: a sequence-based predictor for predicting nucleosome positioning in genomes with pseudo k-tuple nucleotide composition.

Motivation: Nucleosome positioning participates in many cellular activities and plays significant roles in regulating cellular processes. With the avalanche of genome sequences generated in the post-genomic age, it is highly desired to develop automated methods for rapidly and effectively identifying nucleosome positioning. Although some computational methods were proposed, most of them were species specific and neglected the intrinsic local structural properties that might play important roles in determining the nucleosome positioning on a DNA sequence.

Prediction of the types of ion channel-targeted conotoxins based on radial basis function network.

Conotoxins are small disulfide-rich peptide toxins, which have the exceptional diversity of sequences. Because conotoxins are able to specifically bind to ion channels and interfere with neurotransmission, they are considered as the excellent pharmacological candidates in drug design. Appropriate type assignment of newly sequenced mature ion channel-targeted conotoxins with computational method is conducive to explore the biological and pharmacological functions of conotoxins.

Identification of mycobacterial membrane proteins and their types using over-represented tripeptide compositions.

Mycobacterium can cause many serious diseases, such as tuberculosis and leprosy. Its membrane proteins play a critical role for multidrug-resistance and its tenacious survival ability. Knowing the types of membrane proteins will provide novel insights into understanding their functions and facilitate drug target discovery.