Publications by authors named "Shouhei Takatou"
Article Synopsis
- The study investigates the effects of 3,4-Dihydroxybenzalacetone (DBL) and caffeic acid phenethyl ester (CAPE) on the NF-κB signaling pathway in inflammatory responses using RAW 264.7 cells.
- CAPE was found to significantly suppress nitrite production and the activation of NF-κB target genes more effectively than DBL, especially after stimulation with LPS and interferon γ.
- The research indicates that CAPE's inhibitory effects are linked to the modification of thiol groups and reduced phosphorylation of the NF-κB p65 protein, which plays a crucial role in inflammation.
3,4-dihydroxybenzalacetone (DBL) and Caffeic acid phenethyl ester (CAPE) are both catechol-containing phenylpropanoid derivatives with diverse bioactivities. In the present study, we analyzed the ability of these compounds to activate the unfolded protein response (UPR) and the oxidative stress response. When human SH-SY5Y neuroblastoma cells were treated with DBL or CAPE, the expression of endoplasmic reticulum (ER) stress-related genes such as HSPA5, HYOU1, DDIT3, and SEC61b increased to a larger extent in response to CAPE treatment, while that of antioxidant genes such as HMOX1, GCLM, and NQO1 increased to a larger extent in response to DBL treatment.
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