Publications by authors named "Shouhei Miyazaki"
Vascular endothelial cells sustain vascular health through barrier and endocrine functions. Insufficient oxygen supply induces endothelial dysfunction in the pathology of various diseases. In addition, oxygen deprivation reportedly induces endothelial dysfunction via autophagy.
View Article and Find Full Text PDFRAS guanyl nucleotide-releasing proteins (RASGRPs) are important proteins that act as guanine nucleotide exchange factors, which activate small GTPases and function as molecular switches for intracellular signals. The RASGRP family is composed of RASGRP1-4 proteins and activates the small GTPases, RAS and RAP. Among them, RASGRP2 has different characteristics from other RASGRPs in that it targets small GTPases and its localizations are different.
View Article and Find Full Text PDFArticle Synopsis
- - Mental stress leads to negative physiological effects, like anxiety, depression, and changes in brain chemistry, particularly affecting the autonomic nervous system and BDNF levels in the hippocampus.
- - Acanthopanax senticosus HARMS (ASH) shows potential as an anti-anxiety agent, prompting the exploration of its active compounds—chlorogenic acid (CHA) and ( +)-syringaresinol-di-O-β-D-glucoside (SYG)—in male rats for their anxiolytic effects.
- - Both CHA and SYG, especially in combination, improve locomotor activity and enhance hippocampal BDNF protein expression, suggesting these constituents may help alleviate anxiety and positively affect autonomic
Article Synopsis
- The study explores the effects of Eucommia leaf extract (ELE) on obesity, glycolysis, and lipid metabolism in male rats, showing promising anti-obesity outcomes.
- Both 5% ELE and ELE aroma treatments resulted in notable changes in metabolic markers, including increased mRNA levels for important metabolic genes in the liver.
- The findings suggest that ELE enhances lipid metabolism and aerobic glycolysis, potentially aiding in the regulation of metabolic syndrome through the influence of brain-derived neurotrophic factor (BDNF).
Article Synopsis
- Mental stress can lead to physiological changes, including increased autonomic nervous activity and gastric ulcers, while also affecting glucocorticoids and BDNF levels in the hippocampus.
- The study explored the anxiolytic effects of ASH (a herbal extract) on male rats through behavioral tests, revealing that ASH treatment reduced the time to eat in stressful conditions and improved other anxiety-related behaviors.
- Results demonstrated that ASH (especially at 5% concentration) not only altered autonomic nervous activity—as shown by changes in LFnu and HFnu—but also significantly increased BDNF protein expression in the hippocampus, suggesting a potential mechanism for its anxiolytic effects.