Publications by authors named "Shoudi He"
Oridonin (ORI), derived from Chinese herbs , has anti-inflammatory, proapoptotic, anticancer effects. Previous studies have found that ORI induces apoptosis in rheumatoid arthritis fibroblast synovial cells (RA-FLSs), but this mechanism is not clear. We will investigate the apoptosis mechanism of ORI on RA-FLSs.
View Article and Find Full Text PDFBackground: Pulpitis often are characterized as sustained inflammation and impaired pulp self-repair. Circular RNAs (circRNAs) have been reported to be involved in the development of inflammation, but their influence in pulpitis is still unidentified, which was examined in our research.
Methods: In this study, TNF-α (20 ng/mL) was used to treat DPSCs, then MTS identified cell proliferation.
Article Synopsis
- - Baicalin has various health benefits, including anti-inflammatory and antibacterial properties, but its role in treating Adriamycin-induced nephrotic syndrome (NS) isn't fully understood.
- - In a study with rats, researchers found that baicalin improved kidney function and caused significant changes in the expression of 363 genes related to EMT, fibrosis, apoptosis, and inflammation in those with Adriamycin-induced NS.
- - The findings suggest that baicalin could be a promising treatment for NS by reducing inflammation and fibrosis, indicating potential therapeutic genes for future research.
Objective: To investigate lncRNAs and their roles in regulating the pulmonary inflammatory response under dexamethasone (Dex) treatment.
Methods: IL-1β (10 ng/mL) and LPS (1 μg/mL) was used to construct inflammatory cell models with A549 cells; IL-1β performed better against LPS. Different concentrations of Dex were used to attenuate the inflammation induced by IL-1β, and its effect was assessed via RT-PCR to detect inflammatory cytokine-related mRNA levels, including those of IKβ-α, IKKβ, IL-6, IL-8, and TNF-α.
There is little evidence regarding the roles of long noncoding RNAs (lncRNAs) in inflammation caused by asthma. In this study, we successfully generated an asthma mouse model that was induced by ovalbumin (OVA). The effects of dexamethasone (Dex) treatment on lung tissue were investigated using pathological and biochemical methods, including Diff-Quik staining, enzyme-linked immunosorbent assay (ELISA), hematoxylin-eosin (H&E) staining, and western blotting (WB).
View Article and Find Full Text PDFOridonin exhibits various pharmacological and physiological activities, including antioxidant, antibacterial, anti-inflammatory, pro-apoptotic, anticancer and neurological effects. However, its role in rheumatoid arthritis (RA) is yet to be revealed. We evaluated the effects of oridonin on the survival and autophagy of RA-fibroblast-like synoviocytes (FLSs).
View Article and Find Full Text PDFArticle Synopsis
- Melittin, found in honeybee venom, shows potential as a treatment for Rheumatoid Arthritis (RA) by reducing inflammation and pain.
- This study examined melittin's effects on fibroblast-like synoviocytes (FLS) from RA patients, specifically its impact on cell survival, apoptosis, and inflammatory processes.
- Findings revealed that melittin decreases FLS viability, encourages apoptosis and autophagy, and lowers IL-1β secretion, suggesting it may help protect joints from damage in RA.