Missense variants in CYP4B1 associated with increased risk of lung cancer among Chinese Han population.

Introduction: Understanding the etiology and risk factors of lung cancer (LC) is the key to developing scientific and effective prevention and control strategies for LC. CYP4B1 genetic polymorphism has been reported to be associated with susceptibility to various diseases. We aimed to explore the association between CYP4B1 genetic variants and LC susceptibility.

Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk.

Lung cancer is one of the malignant tumors, and genetic background is a risk factor in lung cancer that cannot be neglected. In this study, we aimed to find out the effect of MRPS30-DT and NINJ2 variants on lung cancer risk. In this study, the seven selected single-nucleotide polymorphisms (SNPs) of MRPS30-DT and NINJ2 were genotyped in 509 lung cancer patients and 501 healthy controls based on the Agena MassARRAY platform.

Single nucleotide polymorphism in the 3' untranslated region of LPP is a risk factor for lung cancer: a case-control study.

Background: Single nucleotide polymorphisms (SNPs) in 3'-untranslated region (UTR) of genes related with cell-matrix adhesions and migration might affect miRNA binding and potentially affect the risk of cancer. The present study aimed to screen SNPs in 3' UTR of cancer-related genes and investigate their contribution to the susceptibility of lung cancer.

Methods: Seven SNPs were selected and genotyped in a case-control study (322 lung cancer patients and 384 controls) among Chinese Han population.

RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population.

RTEL1 (regulator of telomere elongation helicase 1; OMIM 608833) gene polymorphisms were linked to lung cancer (LC) susceptibility in a cancer genome-wide association study (GWAS) Here, we assessed whether seven previously reported RTEL1 polymorphisms influenced LC risk in Han Chinese population. All study samples (554 LC cases and 696 cancer-free controls) were collected from the Affiliated Hospital of Xizang Minzu University in China. We assessed associations between SNPs and LC risk using various several genetic models (codominant, dominant, recessive, overdominant, and additive).

Plasma Adiponectin Concentrations and Adiponectin Gene Polymorphisms Are Associated with Bronchial Asthma in the Chinese Li Population.

The purpose of this study was to determine the clinical significance of changes in the plasma adiponectin concentration in patients with bronchial asthma and to test the association between the single nucleotide polymorphisms (SNPs) rs2241766 and rs1501299 in the ADIPOQ gene and bronchial asthma in the Chinese Li population. We selected 120 cases and 120 controls, and plasma adiponectin, interleukin (IL)-6, and tumor necrosis factor-alpha (TNF-α) levels were measured by enzyme-linked immunosorbent assay (ELISA). In addition, we genotyped two tag single nucleotide polymorphisms (tSNPs) and evaluated their association with bronchial asthma using the χ2 test and genetic model analysis.