[Liver X receptor attenuates renal ischemia-reperfusion injury in mice].

Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid decline in renal function. Renal ischemia-reperfusion injury (RIRI) is one of the main causes of AKI with the underlying mechanism incompletely clarified. The liver X receptors (LXRs), including LXRα and LXRβ, are members of the nuclear receptor superfamily.

Osteoporosis Caused by Monoallelic Variant of WNT1 Gene in Four Pediatric Patients.

Pediatric patients of autosomal dominant early onset osteoporosis conferred by heterozygous mutation in the WNT1 (OMIM: 615221) were rarely reported, and therapy in pediatrics is relatively inexperienced. The clinical and genotypic characteristics and treatment process of four children with osteoporosis caused by WNT1 monoallelic variation were analyzed. The patients admitted from June 2023 to January 2024.

Therapeutic effect of mesenchymal stem cell-derived exosome therapy for periodontal regeneration: a systematic review and meta-analysis of preclinical trials.

Background: To assess the therapeutic effects of mesenchymal stem cell (MSC)-derived exosome therapy on periodontal regeneration and identify treatment factors associated with enhanced periodontal regeneration in recent preclinical studies.

Methods: Searches were conducted in PubMed, Cochrane Library, EMBASE, and Web of Science databases until October 10, 2024. A risk of bias (ROB) assessment was performed using the SYRCLE tool.

Association between the C-reactive protein-triglyceride-glucose index and endometriosis: a cross-sectional study using data from the national health and nutrition examination survey, 1996-2006.

Background: The C-reactive protein-triglyceride glucose index (CTI) is a promising new marker for evaluating the severity of inflammation. Endometriosis (EM) is a prevalent chronic inflammatory condition influenced by estrogen, primarily affecting women of reproductive age. However, no study has demonstrated an association between the CTI and EM.

Cardiovascular mortality risk among small bowel adenocarcinoma patients: a population-based study.

Background: The objective of this research is to statistically assess the risk of cardiovascular mortality (CVM) between patients with small bowel adenocarcinoma (SBA) and the general population. Additionally, it aims to identify CVM-associated risk factors among individuals with SBA.

Methods: Data obtained between 2000 and 2017 on SBA patients from the Surveillance, Epidemiology, and End Results (SEER) database were examined.

Gentiopicroside ameliorates psoriasis-like skin lesions in mice via regulating the Keap1-Nrf2 pathway and inhibiting keratinocyte activation.

Psoriasis is a chronic, systemic immune-mediated skin disease. Although many new strategies for psoriasis treatment have been developed, there is great need in clinic for treating psoriasis. Gentiopicroside (GPS), derived from Gentiana manshurica Kitagawa, has multiple pharmacological activities including anti-inflammatory, anti-oxidative and antiviral activities.

Integrated irrigation and nitrogen optimization is a resource-efficient adaptation strategy for US maize and soybean production.

Climate change poses substantial challenges to agriculture and crop production, but the combined role of nitrogen and water inputs in adaptation has been largely overlooked. Here, by developing regression models using US county-level data (2008-2020), we demonstrate that integrated optimization of irrigation and nitrogen inputs represents the most resource-efficient strategy to offset the climate-related yield losses. Under the 1.

Identification of CT based radiomic biomarkers for progression free survival in head and neck squamous cell carcinoma.

This study addresses the limited noninvasive tools for Head and Neck Squamous Cell Carcinoma (HNSCC) progression-free survival (PFS) prediction by identifying Computed Tomography (CT)-based biomarkers for predicting prognosis. A retrospective analysis was conducted on data from 203 HNSCC patients. An ensemble feature selection involving correlation analysis, univariate survival analysis, best-subset selection, and the LASSO-Cox algorithm was used to select functional features, which were then used to build final Cox Proportional Hazards models (CPH).

An ensemble multi-dimensional randomization network for intelligent recognition of tobacco baking stage.

In recent years, image processing technology has been increasingly studied on intelligent unmanned platforms, and the differences in the shooting environment during tobacco baking pose challenges to image processing algorithms. To address this problem, an ensemble multi-dimensional randomization network (EMRNet) for intelligent recognition of tobacco baking stage is proposed. The first is to obtain the tobacco leaf area during the baking process.

Two-dimensional non-Hermitian skin effect in an ultracold Fermi gas.

The concept of non-Hermiticity has expanded the understanding of band topology, leading to the emergence of counter-intuitive phenomena. An example is the non-Hermitian skin effect (NHSE), which involves the concentration of eigenstates at the boundary. However, despite the potential insights that can be gained from high-dimensional non-Hermitian quantum systems in areas such as curved space, high-order topological phases and black holes, the realization of this effect in high dimensions remains unexplored.

Development of a nomogram for predicting malignancy in BI-RADS 4 breast lesions using contrast-enhanced ultrasound and shear wave elastography parameters.

This study aimed to develop a Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression (LR) model using quantitative imaging features from Shear Wave Elastography (SWE) and Contrast-Enhanced Ultrasound (CEUS) to assess the malignancy risk of BI-RADS 4 breast lesions (BLs). The features predictive of malignancy in the LASSO analysis were used to construct a nomogram. Female patients (n = 111) with BI-RADS 4 BLs detected via routine ultrasound at Ma'anshan People's Hospital underwent SWE, CEUS, and histopathological examinations were enrolled in this study.

Understanding Awareness, Utilization, and the Awareness-Utilization Gap of HIV PrEP and nPEP Among Young MSM in China.

HIV/AIDS remains a significant public health challenge in China, particularly among men who have sex with men (MSM). Pre-Exposure Prophylaxis (PrEP) and non-occupational post-exposure Prophylaxis (nPEP) are effective interventions to reduce HIV transmission in high-risk populations. This study assessed awareness and utilization levels of PrEP and nPEP among young MSM (YMSM) aged 18-29 in China and examined associated factors.

Delocalized Nonbonding Orbitals of Thioxanthone in Polycyclic Aromatic Hydrocarbons for Reduced Energy Gap and Narrowband Emission.

Chalcogen-containing carbonyls, specifically thioxanthone (TX), hold great potential in organic light-emitting diodes (OLEDs). While the development of narrowband OLEDs with chalcogen-containing carbonyls remains challenging due to difficulties in achieving both high device efficiency and narrow emission spectra. Herein, via a strategic incorporation of the TX moiety, two orange-red narrowband emitters, 2TXBN and BNTXBN, are designed and synthesized for the first time.

Immunoregulatory programs in anti-N-methyl-D-aspartate receptor encephalitis identified by single-cell multi-omics analysis.

Background: Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is a prevalent type of autoimmune encephalitis caused by antibodies targeting the NMDAR's GluN1 subunit. While significant progress has been made in elucidating the pathophysiology of autoimmune diseases, the immunological mechanisms underlying anti-NMDARE remain elusive. This study aimed to characterize immune cell interactions and dysregulation in anti-NMDARE by leveraging single-cell multi-omics sequencing technologies.

Machine Learning for In-hospital Mortality Prediction in Critically Ill Patients With Acute Heart Failure: A Retrospective Analysis Based on the MIMIC-IV Database.

Background: The incidence, mortality, and readmission rates for acute heart failure (AHF) are high, and the in-hospital mortality for AHF patients in the intensive care unit (ICU) is higher. However, there is currently no method to accurately predict the mortality of AHF patients.

Methods: The Medical Information Mart for Intensive Care Ⅳ (MIMIC-Ⅳ) database was used to perform a retrospective study.

Application of Ultrashort Implants in Posterior Maxilla With Insufficient Bone Height: A Finite Element Analysis.

Introduction And Aims: Implantation of the posterior maxilla with insufficient bone height faces challenges. Studies have shown that the use of ultrashort implants can avoid additional damage. This finite element analysis study aimed to evaluate the impacts of different lengths of ultrashort implants and three surgical approaches on stress, strain, and displacement in the posterior maxilla with varying bone heights.

Chrysanthemum morifolium Ramat. as a traditional tea material: Unraveling the influence of kill-green process on drying characteristics, phytochemical compounds, and volatile profile.

The dried capitulum of chrysanthemums is a traditional material in scented tea, and the kill-green process is a critical step in determining their quality. However, the changes in the physicochemical properties during kill-green and the mechanisms by which these changes affect drying characteristics, metabolic components, and aroma profiles remain unclear. Therefore, this study investigated the changes in water status, polyphenol oxidase and peroxidase activities, and microstructure during high-humidity air impingement kill-green (HHAIK) and steam kill-green (SK), and their effects on drying behavior, color, phytochemicals, and volatile profile of dried chrysanthemums.

Prediction of individual total amino acids and free amino acids in Chinese Holstein cows milk using mid-infrared spectroscopy and their phenotypic variability.

Establishing a high-throughput detection technology for amino acid (AA) content in milk using mid-infrared (MIR) spectroscopy has profound implications for enhancing nutritional value of milk, identifying superior milk sources, producing specialty dairy products, and expanding Dairy Herd Improvement (DHI) metrics. The aim of this study was to evaluate the effectiveness of MIR spectroscopy in predicting the content of 15 individual total AA (TAAs) and 16 free AA (FAAs) in bovine milk as well as to investigate the major factors affecting the phenotypic variability of AA content. From March 2023 to March 2024, 513 milk samples were collected from 10 Holstein dairy farms in China and analyzed using Bentley spectrometers for MIR measurements.

De-starched Panax ginseng polysaccharide: Preparation, in vitro digestion, fermentation properties and the activating effect of the resultant products on RAW264.7 cells.

Panax ginseng C. A. Meyer (ginseng) neutral polysaccharides have been proven to be an immune enhancer, but their digestion and fermentation characteristics are unclear.

Preparation, characterization and antibacterial investigation of water-soluble curcumin-chitooligosaccharide complexes.

Curcumin has a wide range of application prospects, with various bioactivities in the food industry and in the biomedical field. However, curcumin has poor water solubility and is sensitive to pH, light and temperature. In this study, curcumin-chitooligosaccharide (CUR-COS) complexes were prepared via mechanochemical methods, and the CUR-COS complex was more soluble after freeze-drying (up to 862-fold greater than that of curcumin).

A β-cyclodextrin-based supramolecular photonic crystal hydrogel biosensor with macroporous structures for naked-eye visual detection of cholesterol.

Cholesterol (CHO) is an essential lipid in cell membranes and a precursor for vital living substances. Abnormal CHO levels can cause cardiovascular diseases. Therefore, simple and accurate monitoring of CHO levels is crucial for early diagnosis and effective management of cardiovascular diseases.

Effect and Mechanism of an ACT-Based Psychological Resilience Intervention Targeting Students Failing in Postgraduate Entrance Examinations in China: A Randomized Controlled Trial.

The postgraduate entrance examination frenzy is a widespread and intense phenomenon in China. As the number of students who failed the examination surged, the ensuing mental health problems became prominent. This study aimed to evaluate the effectiveness of an online ACT-based group resilience course, which incorporated the six core components of ACT and integrated elements of Chinese culture, in alleviating psychological distress among students who failed the examination.

Cadmium exposure induces inflammation, oxidative stress and DNA damage in HUVEC and promotes THP-1 adhesion: a possible mechanism on the formation of Atherosclerotic plaque.

Observational studies have shown that cadmium exposure increases the risk of cardiovascular disease, but the underlying mechanism is still unclear. Atherosclerotic plaque can cause vascular obstruction, which is important for the death from cardiovascular disease. Cell damage and monocyte adhesion are two early events in atherosclerotic plaque formation that can be induced by cadmium exposure, but the mechanism remains to be determined.

Thermal decomposition synthesis of CuO on TiO NTs as promising photocatalysts for effective photoelectrocatalytic hydrogen evolution and pollutant removal.

The preparation strategy is the important factor to obtain the effective photocatalyst, and the thermal decomposition could be used to prepare photocatalysts with high crystallinity and photoactivity. In this paper, thermal decomposition method was used to deposit CuO nanoparticles on TiO nanotube arrays (TiO NTs), and the TiO NTs/CuO exhibited remarkably high visible light absorption and photoelectrocatalytic performances toward dye degradation and Cr(VI) reduction. The potential degradation pathway and toxicities of rhodamine B (RhB) dyes and intermediates were investigated.